Androgen deprivation-induced senescence explained

Androgen deprivation-induced senescence (or ADIS) refers to the induction of cellular senescence as a result of androgen deprivation therapy.[1] [2] [3] [4] [5] ADIS is observed in prostate cancer cells that are dependent on androgens for cell proliferation. Androgen withdrawal induces cells to undergo cellular senescence by up-regulating intracellular reactive oxygen species (ROS) that cause DNA damage. ADIS is maintained through the up-regulation of the cell cycle regulator p16ink4a.

Notes and References

  1. Pernicová. Z. Slabáková, E. Kharaishvili, G. Bouchal, J. Král, M. Kunická, Z. Machala, M. Kozubík, A. Souček, K. Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2. Neoplasia. June 2011. 13. 6. 526–36. 21677876. 3114246. 10.1593/neo.11182.
  2. Ewald. JA. Desotelle, JA. Church, DR. Yang, B. Huang, W. Laurila, TA. Jarrard, DF. Androgen deprivation induces senescence characteristics in prostate cancer cells in vitro and in vivo. The Prostate. March 2013. 73. 4. 337–45. 22911222. 10.1002/pros.22571. 4753826.
  3. Burton. Dominick G. A.. Giribaldi, Maria G.. Munoz, Anisleidys. Halvorsen, Katherine. Patel, Asmita. Jorda, Merce. Perez-Stable, Carlos. Rai, Priyamvada. Agoulnik, Irina U.. Androgen Deprivation-Induced Senescence Promotes Outgrowth of Androgen-Refractory Prostate Cancer Cells. PLOS ONE. 27 June 2013. 8. 6. e68003. 10.1371/journal.pone.0068003. 23840802. Agoulnik. Irina U. 3695935. 2013PLoSO...868003B . free.
  4. Barakat et al (2015). CCAAT/Enhancer binding protein β controls androgen-deprivation-induced senescence in prostate cancer cells Oncogene
  5. Kawata. Hirotoshi. Kamiakito. Tomoko. Nakaya. Takeo. Komatsubara. Maiko. Komatsu. Kenji. Morita. Tatsuo. Nagao. Yasumitsu. Tanaka. Akira. Stimulation of cellular senescent processes, including secretory phenotypes and anti-oxidant responses, after androgen deprivation therapy in human prostate cancer. The Journal of Steroid Biochemistry and Molecular Biology. 10.1016/j.jsbmb.2016.06.007. 27329245. 165. Pt B. 219–227. 2017. 6273648.

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