Andrew Singleton Explained

Andrew Singleton
Birth Name:Andrew B. Singleton
Birth Date:1972
Birth Place:Guernsey, the Channel Islands
Fields:Neuroscience
Known For:Parkinson's disease research

Andrew B. Singleton is a British neurogeneticist currently working in the USA. He was born in Guernsey, the Channel Islands in 1972, where he lived until he was 18 years old. His secondary education was conducted at the Guernsey Grammar School. He earned a first class degree in Applied Physiology from Sunderland University and his PhD in neuroscience from the University of Newcastle upon Tyne where he studied the genetics of Alzheimer's disease and other dementias at the Medical Research Council (MRC) Neurochemical Pathology Unit. He moved to the United States in 1999, where he began working at the Mayo Clinic in Jacksonville, Florida studying the genetic basis of Parkinson's disease, ataxia, and dystonia. He moved to the National Institutes of Health in 2001 to head the newly formed Molecular Genetics unit within the Laboratory of Neurogenetics. In 2006 he took over as Chief of the Laboratory of Neurogenetics and became an NIH Distinguished Investigator in the intramural program at the National Institute on Aging (NIA) in 2017. In 2020 he stepped down as the Chief of the Laboratory of Neurogenetics and became the Acting Director of the newly formed Center for Alzheimer's and Related Dementias at the NIA (CARD https://card.nih.gov/). In 2021 he became the Director of CARD.

Accomplishments

Dr. Singleton is best known for his work aimed at understanding the genetic etiology of Parkinson's disease. His first well-known work described the discovery of a triplication mutation of the alpha-synuclein gene that causes a severe, early-onset form of Parkinson's disease.[1] One year later he led the group that was the first to identify mutations in the LRRK2 gene as a cause of familial Parkinson's disease, as well as the more common, sporadic Parkinson's disease.[2] Since then, his laboratory has focused more on the complex genetics of Parkinson's disease, describing more than 90 common genetic risk factors for this disease.[3] [4] [5] In addition to working on Parkinson's disease and other neurological disorders, his laboratory has active research programs investigating genetic diversity and the consequences of genetic alterations, particularly in the context of the brain and ageing, using systems biology-based approaches.[6] [7] [8] To date he has published more than 700 scientific articles.[9]

Awards and honours

Notes and References

  1. 10.1126/science.1090278 . α-Synuclein Locus Triplication Causes Parkinson's Disease . 2003 . Singleton . A. B. . Science . 302 . 5646 . 841 . 14593171 . Farrer . M . Johnson . J . Singleton . A . Hague . S . Kachergus . J . Hulihan . M . Peuralinna . T . Dutra . A. 85938327 . 8.
  2. 595–600 . 10.1016/j.neuron.2004.10.023 . Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease . 2004 . Paisán-Ruı́z . Coro . Jain . Shushant . Evans . E.Whitney . Gilks . William P. . Simón . Javier . Van Der Brug . Marcel . De Munain . Adolfo López . Aparicio . Silvia . Gil . Angel Martı́nez . 8. Neuron . 44 . 4 . 15541308. 16688488 . free .
  3. 1308–12 . 10.1038/ng.487 . 2787725 . Genome-wide association study reveals genetic risk underlying Parkinson's disease . 2009 . Simón-Sánchez . Javier . Schulte . Claudia . Bras . Jose M . Sharma . Manu . Gibbs . J Raphael . Berg . Daniela . Paisan-Ruiz . Coro . Lichtner . Peter . Scholz . Sonja W . 8. Nature Genetics . 41 . 12 . 19915575.
  4. 641–9 . 10.1016/S0140-6736(10)62345-8 . Imputation of sequence variants for identification of genetic risks for Parkinson's disease: A meta-analysis of genome-wide association studies . 2011 . The Lancet . 377 . 9766 . 21292315 . 3696507. International Parkinson Disease Genomics Consortium . Nalls . M. A. . Plagnol . V. . Hernandez . D. G. . Sharma . M. . Sheerin . U. M. . Saad . M. . Simón-Sánchez . J. . Schulte . C. . Lesage . S. . Sveinbjörnsdóttir . S. . Stefánsson . K. . Martinez . M. . Hardy . J. . Heutink . P. . Brice . A. . Gasser . T. . Singleton . A. B. . Wood . N. W. .
  5. 10.1371/journal.pgen.1002142 . 3128098 . A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease . 2011 . Gibson . Greg . PLOS Genetics . 7 . 6 . e1002142 . 21738488 . International Parkinson's Disease Genomics Consortium (IPDGC) . Wellcome Trust Case Control Consortium 2 (WTCCC2) . free .
  6. 998–1003 . 10.1038/nature06742 . Genotype, haplotype and copy-number variation in worldwide human populations . 2008 . Jakobsson . Mattias . Scholz . Sonja W. . Scheet . Paul . Gibbs . J. Raphael . Vanliere . Jenna M. . Fung . Hon-Chung . Szpiech . Zachary A. . Degnan . James H. . Wang . Kai . 8. Nature . 451 . 7181 . 18288195. 2008Natur.451..998J . 2027.42/62552 . 11074384 . free .
  7. 10.1371/journal.pgen.1000952 . 2869317 . Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain . 2010 . Flint . Jonathan . Gibbs . J. Raphael . Van Der Brug . Marcel P. . Hernandez . Dena G. . Traynor . Bryan J. . Nalls . Michael A. . Lai . Shiao-Lin . Arepalli . Sampath . Dillman . Allissa . Rafferty . Ian P. . 8. PLOS Genetics . 6 . 5 . e1000952 . 20485568 . free .
  8. 1164–72 . 10.1093/hmg/ddq561 . 3043665 . Distinct DNA methylation changes highly correlated with chronological age in the human brain . 2011 . Hernandez . D. G. . Nalls . M. A. . Gibbs . J. R. . Arepalli . S. . Van Der Brug . M. . Chong . S. . Moore . M. . Longo . D. L. . Cookson . M. R. . 8. Human Molecular Genetics . 20 . 6 . 21216877.
  9. Web site: Andrew B. Singleton, Ph.D. Principal Investigators NIH Intramural Research Program . 2024-01-18 . irp.nih.gov.
  10. Web site: September 14, 2023 . BREAKTHROUGH PRIZE ANNOUNCES 2024 LAUREATES IN LIFE SCIENCES, FUNDAMENTAL PHYSICS, AND MATHEMATICS . September 14, 2023 . BREAKTHROUGH PRIZE.

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