Andrew Oates Explained

Honorific Prefix:Professor
Andrew Oates
Birth Place:Adelaide, Australia
Citizenship:Australian
British
Occupation:Full Professor
Known For:Segmentation of the zebrafish body axis by the genetic oscillations
Website:https://www.epfl.ch/labs/oateslab/
Education:Biology
Alma Mater:University of Adelaide
University of Melbourne
Doctoral Advisor:Andrew F Wilks
Academic Advisors:Robert Ho
Discipline:Biology
Sub Discipline:Embryology
Workplaces:EPFL (École Polytechnique Fédérale de Lausanne)
Main Interests:Developmental biology
Genetic oscillations
Biophysics
Embryology
Synchronization

Andrew 'Andy' Charles Oates (born 1969 in Adelaide, Australia) is an Australian and British developmental biologist and embryologist specialized in biological pattern formation. He is professor at EPFL (École Polytechnique Fédérale de Lausanne) and head of the Segmentation Timing and Dynamics Laboratory at EPFL's School of Life Sciences.[1] [2] [3] Since 2021, he has been dean of EPFL's School of Life Sciences.

Career

Oates received an undergraduate degree in biochemistry with honors for his work at the Robert Saint's laboratory at the University of Adelaide in 1992. He then joined Andrew F. Wilks at the Ludwig Institute for Cancer Research and at the University of Melbourne as PhD student, and graduated in 1998.[4] His postdoctoral time was at the laboratory of Robert Ho both at Princeton University and at University of Chicago, where he began his studies on the segmentation clock in zebrafish.[5] In 2003, he moved to the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden to start his research group.[6] [7] In 2012, he became professor of vertebrate developmental genetics at University College London and moved his group to the National Institute for Medical Research at Mill Hill in London.[8] In April 2015, he became a member of the Francis Crick Institute in London.[9]

In 2016, he joined EPFL as a full professor, where he is the founder and director of the Timing, Oscillation, Patterns Laboratory at EPFL's School of Life Sciences.

Since 2018, he has served as director of the EPFL's Institute of Bioengineering,[10] and since January 2021 he has been the dean of the EPFL's School of Life Sciences.[11]

Research

Oates' research laboratory is composed of biologists, engineers, and physicists. It draws on molecular genetics, quantitative imaging, and theoretical analysis in order to investigate populations of coupled genetic oscillators in vertebrate embryos, termed as segmentation clocks.[12] These systems drive the rhythmic, sequential, and precise formation of embryonic body segments, exhibiting rich spatial and temporal phenomena spanning from molecular to tissue scales.[13] [14]

The laboratory' contributions are the direct connection of genes to segmentation rhythm, and the discovery that the rhythm also involves physical, collective processes at multi-cellular and tissue scales.[15] [16]

Distinctions

Oates is a member of the British Society of Developmental Biology.[17] He is the recipient of the R.K. Mortenson Prize for Biochemistry 1991.

Selected works

External links

Notes and References

  1. Web site: Brexit: closer cooperation with the UK cannot replace participation in Horizon 2020 ETH-Board. 2020-12-21. www.ethrat.ch. 9 January 2021. https://web.archive.org/web/20210109174027/https://www.ethrat.ch/en/medien-medienmitteilungen/brexit-engere-zusammenarbeit-mit-grossbritannien-kann-teilnahme-horizon-2020-nicht-ersetzen. dead.
  2. Web site: oateslab. 2020-12-21. www.epfl.ch. en-GB.
  3. Web site: Andrew Charles Oates. 2020-12-21. people.epfl.ch.
  4. Nicholson. S. E.. Oates. A. C.. Harpur. A. G.. Ziemiecki. A.. Wilks. A. F.. Layton. J. E.. 1994-04-12. Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.. Proceedings of the National Academy of Sciences. en. 91. 8. 2985–2988. 10.1073/pnas.91.8.2985. 0027-8424. 43499. 7512720. 1994PNAS...91.2985N . free .
  5. Oates. Andrew C. Bruce. Ashley E.E. Ho. Robert K. August 2000. Too Much Interference: Injection of Double-Stranded RNA Has Nonspecific Effects in the Zebrafish Embryo. Developmental Biology. en. 224. 1. 20–28. 10.1006/dbio.2000.9761. 10898958. free.
  6. Schröter. Christian. Herrgen. Leah. Cardona. Albert. Brouhard. Gary J.. Feldman. Benjamin. Oates. Andrew C.. March 2008. Dynamics of zebrafish somitogenesis. Developmental Dynamics. en. 237. 3. 545–553. 10.1002/dvdy.21458. 18265021. 7038940. free.
  7. Uriu. Koichiro. Ares. Saúl. Oates. Andrew C.. Morelli. Luis G.. 2013-03-21. Dynamics of mobile coupled phase oscillators. Physical Review E. en. 87. 3. 032911. 10.1103/PhysRevE.87.032911. 2013PhRvE..87c2911U . 11336/2452 . 1539-3755. free.
  8. Soroldoni. D.. Jorg. D. J.. Morelli. L. G.. Richmond. D. L.. Schindelin. J.. Julicher. F.. Oates. A. C.. 2014-07-11. A Doppler effect in embryonic pattern formation. Science. en. 345. 6193. 222–225. 10.1126/science.1253089. 25013078. 206556621. 0036-8075. 7611034. 2014Sci...345..222S .
  9. Web site: King's College London - Randall Seminar: Professor Andrew Oates. 2020-12-21. www.kcl.ac.uk.
  10. Sanctuary. Hillary. 2020-08-25. Andrew Oates, a Passion for Cycles. en.
  11. 2020-11-12. New deans for the Basic Sciences and Life Sciences. en.
  12. Naganathan. Sundar R.. Oates. Andrew C.. October 2017. Mechanochemical coupling and developmental pattern formation. Current Opinion in Systems Biology. en. 5. 104–111. 10.1016/j.coisb.2017.09.007.
  13. Web site: Research. 2020-12-21. www.epfl.ch. en-GB.
  14. Lleras Forero. Laura. Narayanan. Rachna. Huitema. Leonie FA. VanBergen. Maaike. Apschner. Alexander. Peterson-Maduro. Josi. Logister. Ive. Valentin. Guillaume. Morelli. Luis G. Oates. Andrew C. Schulte-Merker. Stefan. 2018-04-06. Whitfield. Tanya T.. Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock. eLife. 7. e33843. 10.7554/eLife.33843. 29624170. 5962341. 4605280. 2050-084X. free.
  15. Oates. Andrew C. August 2020. Waiting on the Fringe: cell autonomy and signaling delays in segmentation clocks. Current Opinion in Genetics & Development. en. 63. 61–70. 10.1016/j.gde.2020.04.008. 32505051. free.
  16. Venzin. Olivier F.. Oates. Andrew C.. April 2020. What are you synching about? Emerging complexity of Notch signaling in the segmentation clock. Developmental Biology. en. 460. 1. 40–54. 10.1016/j.ydbio.2019.06.024. 31302101. free.
  17. Web site: Newsletter. British Society for Developmental Biology.

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