Andrew Lumsden (scientist) explained
Andrew Gino Lumsden [1] (born 22 January 1947) is an English neurobiologist, Emeritus Professor of the University of London and founder in 2000 of the Medical Research Council Centre for Developmental Neurobiology[2] at King's College London.[3]
Education
Andrew Lumsden attended Kingswood School in Bath, Somerset (as Andrew Sita-Lumsden) and graduated from St. Catharine's College, Cambridge with Double First Class Honours in Natural Sciences. After visiting Yale University for two years as a Fulbright Scholar, he returned to England to complete his PhD in Developmental Biology at the University of London.
Career and research
Lumsden has held various lectureships at Guy's Hospital Medical School and the United Medical Schools of Guy's and St. Thomas' Hospital before being made a full Professor of the University of London in 1989. He has been an International Scholar of the Howard Hughes Medical Institute (1993–1998) and a Miller Institute visiting professor at the University of California, Berkeley (1994).
Lumsden has served on the Medical Research Council Neurosciences and Mental Health Board and Grants Committee (1992—1998), the Wellcome Trust Neuroscience Funding Committee (1997—2000), and the Brain Functions Grant Review Committee of the Human Frontier Science Program (1998—2001). He has also served as editor of Development[4] (1995—2007) and is co-founder of the on-line, open-access journal Neural Development.[5] In addition, Andrew Lumsden is a co-Head of Section for Faculty of 1000.[6]
Andrew Lumsden has co-authored a book entitled The Developing Brain with Michael Brown and Roger Keynes.[7] Following his PhD on epithelial-mesenchymal interactions in mammalian development, Lumsden's interest moved to the question of how integumental structures, such as teeth and vibrissae acquire their nerve supply, and how the cranial neural crest contributes to their patterning. Studies on the development of the trigeminal nerve and ganglion led on to observations of the organisation of their corresponding motor and sensory regions of the central nervous system. His seminal observations and experiments on the developing hindbrain of mammal and bird embryos confirmed the long suggested but never agreed view that this brain region has a rigidly segmented organisation, much like the body plan of insects and worms. To assist his research, he developed the Lumsden BioScissors™.[8] [9] Most recently, he has focussed on the developing forebrain, where he discovered signalling properties in a small set of cells that pattern the large surrounding region of the thalamus.
Awards and honours
Lumsden was elected a Fellow of the Royal Society (elected 1994), a Fellow of the Academy of Medical Sciences (1998), and a Fellow of King's College London (1999). He was also elected an EMBO Member in 2008.
In 2001, he was awarded The Ferrier Lecture and medal by the Royal Society[1] [10] and in 2007, the W. Maxwell Cowan Prize[11] for "outstanding contributions in developmental neuroscience".
Lumsden has also been elected Freeman of the Worshipful Company of Clockmakers in 2006, and raised to the Livery in 2016.
Publications
Lumsden's publications include:
- Lumsden AG, Davies AM . Earliest sensory nerve fibres are guided to peripheral targets by attractants other than nerve growth factor . Nature . 306 . 5945 . 786–8 . 1983 . 6656880 . 10.1038/306786a0 . 1983Natur.306..786L . 4317445 .
- Lumsden AG, Davies AM . Chemotropic effect of specific target epithelium in the developing mammalian nervous system . Nature . 323 . 6088 . 538–9 . 1986 . 3762707 . 10.1038/323538a0 . 1986Natur.323..538L . 4363988 .
- Tessier-Lavigne M, Placzek M, Lumsden AG, Dodd J, Jessell TM . Chemotropic guidance of developing axons in the mammalian central nervous system . Nature . 336 . 6201 . 775–8 . 1988 . 3205306 . 10.1038/336775a0 . 1988Natur.336..775T . 4247407 .
- Lumsden A . Multipotent cells in the avian neural crest . Trends Neurosci. . 12 . 3 . 81–3 . March 1989 . 2469219 . 10.1016/0166-2236(89)90159-8. 31991456 .
- Lumsden A, Keynes R . Segmental patterns of neuronal development in the chick hindbrain . Nature . 337 . 6206 . 424–8 . February 1989 . 2644541 . 10.1038/337424a0 . 1989Natur.337..424L . 4262186 .
- Heffner CD, Lumsden AG, O'Leary DD . Target control of collateral extension and directional axon growth in the mammalian brain . Science . 247 . 4939 . 217–20 . January 1990 . 2294603 . 10.1126/science.2294603 . 1990Sci...247..217H .
- Fraser S, Keynes R, Lumsden A . Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions . Nature . 344 . 6265 . 431–5 . March 1990 . 2320110 . 10.1038/344431a0 . 1990Natur.344..431F . 4355552 .
- Lumsden A . The cellular basis of segmentation in the developing hindbrain . Trends Neurosci. . 13 . 8 . 329–35 . August 1990 . 1699318 . 10.1016/0166-2236(90)90144-Y. 3997227 .
- Lumsden A, Sprawson N, Graham A . Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo . Development . 113 . 4 . 1281–91 . December 1991 . 10.1242/dev.113.4.1281 . 1811942 .
- Guthrie S, Muchamore I, Kuroiwa A, Marshall H, Krumlauf R, Lumsden A . Neuroectodermal autonomy of Hox-2.9 expression revealed by rhombomere transpositions . Nature . 356 . 6365 . 157–9 . March 1992 . 1545869 . 10.1038/356157a0 . 1992Natur.356..157G . 4346647 .
- Simon H, Lumsden A . Rhombomere-specific origin of the contralateral vestibulo-acoustic efferent neurons and their migration across the embryonic midline . Neuron . 11 . 2 . 209–20 . August 1993 . 8394719 . 10.1016/0896-6273(93)90179-U. 35121927 .
- Lumsden A, Clarke JD, Keynes R, Fraser S . Early phenotypic choices by neuronal precursors, revealed by clonal analysis of the chick embryo hindbrain . Development . 120 . 6 . 1581–9 . June 1994 . 10.1242/dev.120.6.1581 . 8050364 .
- Graham A, Francis-West P, Brickell P, Lumsden A . The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest . Nature . 372 . 6507 . 684–6 . December 1994 . 7990961 . 10.1038/372684a0 . 1994Natur.372..684G . 4361935 .
- Logan C, Wizenmann A, Drescher U, Monschau B, Bonhoeffer F, Lumsden A . Rostral optic tectum adopts a caudal phenotype following ectopic Engrailed expression . Current Biology . 6 . 1006–1014 . 1996 . 8805331 . 8 . 10.1016/S0960-9822(02)00645-0. 15159391 . free .
- Lumsden A, Krumlauf R . Patterning the vertebrate neuraxis . Science . 274 . 1109–1115 . 1996 . 8895453 . 5290 . 10.1126/science.274.5290.1109. 1996Sci...274.1109L . 10891464 .
- Studer M, Lumsden A, Ariza-McNaughton L, Bradley A, Krumlauf R . Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1 . Nature . 384 . 630–634 . 1996 . 8967950 . 10.1038/384630a0 . 6610. 1996Natur.384..630S . 4317559 .
- Bell E, Wingate, R. Lumsden A.. Homeotic transformation of rhombomere identity following localised Hoxb1 misexpression . Science . 284 . 2168–2171 . 1999 . 10381880 . 5423 . 10.1126/science.284.5423.2168.
- Fortin G, Jungbluth S, Lumsden A, Champagnat J . Segmental specification of GABAergic inhibition during development of hindbrain neural networks . Nature Neuroscience . 2 . 873–877 . 1999 . 10491606 . 10.1038/13172 . 10. 27168904 .
- Zeltser L, Larsen C, Lumsden A . A new developmental compartment in the forebrain regulated by Lunatic fringe . Nature Neuroscience . 4 . 683–684 . 2001 . 11426219 . 10.1038/89455 . 7. 26205097 .
- Larsen C, Zeltser L, Lumsden A . Boundary formation and compartition in the avian diencephalon . Journal of Neuroscience . 21 . 4699–4711 . 2001 . 11425897 . 10.1523/jneurosci.21-13-04699.2001 . 13. 6762343 . free .
- Matsumoto K, Nishihara S, Kamimura M, Shiraishi T, Otoguro T, Uehara M, Maeda Y, Ogura K, Lumsden A, Ogura T . The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation . Nature Neuroscience . 7 . 605–612 . 2004 . 15133517 . 10.1038/nn1249 . 6. 23807922 .
- Kiecker C, Lumsden A . Hedgehog signalling from the zona limitans intrathalamica regulates the emergence of thalamic and prethalamic identity . Nature Neuroscience . 7 . 1242–1249 . 2004 . 15494730 . 10.1038/nn1338 . 11. 29863625 .
- Kiecker C, Lumsden A . Compartments and their boundaries in vertebrate brain development . Nature Reviews Neuroscience . 6 . 553–564 . 2005 . 15959467 . 10.1038/nrn1702 . 7. 10869618 .
- Scholpp S, Delogu A, Gilthorpe J, Peukert D, Lumsden A . Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus . Proceedings of the National Academy of Sciences of the United States of America . 106 . 19895–19900 . 2009 . 19903880 . 10.1073/pnas.0910894106 . 47 . 2775703. 2009PNAS..10619895S . free .
- Scholpp S, Lumsden A . Building a bridal chamber: development of the thalamus . Trends in Neurosciences . 33 . 373–380 . 2010 . 20541814 . 10.1016/j.tins.2010.05.003 . 8 . 2954313.
- Delogu A, Sellers K, Zagoraiou L, Bocianowska-Zbrog A, Mandal S, Guimera J, Rubenstein JL, Sugden D, Jessell T, Lumsden A . Subcortical visual shell nuclei targeted by ipRGCs develop from a Sox14+-GABAergic progenitor and require Sox14 to regulate daily activity rhythms . Neuron . 75 . 648–662 . 2012 . 22920256 . 10.1016/j.neuron.2012.06.013 . 4. free .
- Gilthorpe JD, Oozeer F, Nash J, Calvo M, Bennett DL, Lumsden A, Pini A . Extracellular histone H1 is neurotoxic and drives a pro-inflammatory response in microglia. F1000Research . 2. 2013 . 24358859 . 10.12688/f1000research.2-148.v1. 3782347 . 148 . free .
Notes and References
- Web site: Anon . 1994 . Professor Andrew Lumsden FMedSci FRS . royalsociety.org . dead . https://web.archive.org/web/20151012222905/https://royalsociety.org/people/andrew-lumsden-11842/ . 12 October 2015 .
- Web site: King's College London - Department of Developmental Neurobiology. www.kcl.ac.uk.
- Web site: Lumsden Official Page . dead . https://web.archive.org/web/20101210214243/http://www.kcl.ac.uk/depsta/biomedical/mrc/index.php?page=http%3A%2F%2Fwww.kcl.ac.uk%2Fdepsta%2Fbiomedical%2Fmrc%2FResearchGroup.php%3FGroupID%3D18 . 10 December 2010 .
- Web site: Development - The Company of Biologists.
- Web site: Neural Development. Neural Development.
- Web site: Andrew Lumsden: Advisory Board Member in Neurodevelopment: F1000Prime . f1000biology.com . dead . https://web.archive.org/web/20100201160613/http://f1000biology.com/about/biography/1000251023259107 . 1 February 2010 .
- Book: Brown, Michael. Roger Keynes . Andrew Lumsden . The Developing Brain. Oxford University Press. February 14, 2002. 978-0-19-854793-8.
- Web site: Lumsden Bioscissors™ . bio-rad.com . dead . https://web.archive.org/web/20110726222534/http://www.bio-rad.com/LifeScience/pdf/bioscissors.pdf . 26 July 2011 .
- Web site: Obanpi . obanpi.co.uk . dead . https://web.archive.org/web/20110709030309/http://obanpi.co.uk/ . 9 July 2011 .
- Web site: Royal Society prize . dead . https://web.archive.org/web/20030414005949/http://www.royalsoc.ac.uk/royalsoc/mee_ferr.htm . 14 April 2003 .
- Web site: Cowan and Palay Awards . cajalclub.org . dead . https://web.archive.org/web/20110725123132/http://www.cajalclub.org/id17.html . 25 July 2011 .