| Term Start3: | 6 August 2021 |
| Predecessor3: | Nicolae Posturusu |
| Office4: | Deputy Prime Minister of Moldova |
| Term Start4: | 23 July 2021 |
| Office5: | Member of the Moldovan Parliament |
| Office6: | Secretary General of the Government of Moldova |
| Term Start6: | 18 July 2019 |
| Term End6: | 14 November 2019 |
| Office7: | Deputy Minister of Youth and Sport |
| Term Start7: | 12 August 2015 |
| Term End7: | 29 January 2016 |
| Birth Date: | 10 June 1986 |
| Birth Place: | Ratuș, Moldavian SSR, Soviet Union |
| Party: | Party of Action and Solidarity (2019–2024) Liberal Democratic Party (before 2019) |
| Office2: | Secretary General of the Office of the President of Moldova |
| Term Start2: | 6 August 2021 |
| President2: | Maia Sandu |
| President3: | Maia Sandu |
| President6: | Igor Dodon |
| Primeminister6: | Maia Sandu |
| Successor6: | Liliana Iaconi |
| Predecessor6: | Lilia Palii |
| President7: | Nicolae Timofti |
| Primeminister7: | Valeriu Streleț Gheorghe Brega (acting) Pavel Filip |
| Term End4: | 8 September 2021 |
| Successor5: | Boris Popa |
| Successor4: | Vladimir Bolea |
| Minister7: | Loretta Handrabura Victor Zubcu |
| Alma Mater: | Academy of Economic Studies of Moldova (BBA)[1] Harvard Extension School (MiG)[2] |
| Predecessor: | Lilia Dabija |
| Predecessor1: | Vasile Bîtca (2017) (as Minister of Regional Development and Construction) |
| Predecessor2: | Veaceslav Negruța |
| Office: | Minister of Infrastructure and Regional Development |
| Termstart: | 17 July 2023 |
| President: | Maia Sandu |
| Termstart1: | 6 August 2021 |
| Termend1: | 16 February 2023 |
| President1: | Maia Sandu |
| Successor1: | Lilia Dabija |
| Termend2: | 17 July 2023 |
| Termend3: | 9 August 2021 |
| Successor3: | Cristina Gherasimov |
| Primeminister: | Dorin Recean |
| Primeminister1: | Natalia Gavrilița |
| Termstart2: | 16 February 2023 |
| Termestart3: | 24 December 2020 |
| Termstart3: | 24 December 2020 |
| Termstart4: | 6 August 2021 |
| Termend4: | 14 February 2023 |
| President4: | Maia Sandu |
| Primeminister4: | Natalia Gavrilița |
| Predecessor4: | Sergiu Pușcuța |
| Parliamentarygroup5: | Party of Action and Solidarity |
| Termstart5: | 23 July 2021 |
| Termend5: | 8 September 2021 |
| Term End: | 11 November 2024 |
| Successor: | Vladimir Bolea |
Andrei Spînu (; born 10 June 1986[3]) is a Moldovan entrepreneur and politician, who was Deputy Prime Minister of Moldova in the Government of Gavrilița[4] and served as Minister of Infrastructure and Regional Development in the Recean Cabinet.