Andreas Pfaltz Explained

Andreas Pfaltz
Birth Date:	10 May 1948
Birth Place:	Basel, Switzerland
Fields:	Chemistry
Workplaces:	University of Basel Max Planck Institute for Coal Research ETH Zurich
Doctoral Advisor:	Albert Eschenmoser
Thesis Year:	1978
Known For:	chiral ligands, coordination chemistry and catalysis
Awards:	Pracejus Prize (2003) Prelog Medal (2003) Ryoji Noyori Prize (2008) Chirality Medal (2016)

Andreas Pfaltz (born 10 May 1948) is a Swiss chemist known for his work in the area of coordination chemistry and catalysis.

Education and professional life

Andreas Pfaltz studied at ETH Zurich, completing his undergraduate diploma in natural sciences in 1972 and his PhD in organic chemistry in 1978. His doctoral supervisor was Albert Eschenmoser, whose research into vitamin B₁₂ and other corrin rings would influence Pfaltz's early research.^[1] Following a two-year postdoctoral position at Columbia University (early 1978 – late 1979), working for Gilbert Stork on the synthesis of Rifamycin,^[2] he returned to ETH Zurich as a lecturer and began his own research. In 1990 he was appointed as an associate professor at the University of Basel, becoming a full professor in 1993. Between 1995 and 1998 he was a director of the prestigious Max Planck Institute for Coal Research, afterwards returning to the University of Basel, where he has remained till the present day.

Research

Pfaltz's early research was influenced by his PhD supervisor Albert Eschenmoser and was largely based around the synthesis of corrins,^[3] porphyrins^[4] and other macrocycles. During the second half of the 1980s he began to use fragments of these macrocycles as novel ligands for asymmetric catalysis, with chiral C₂-symmetric semicorrins being the most successful example.^{[5] [6]} Following the development of structurally related bis(oxazoline)s Pfaltz began using and developing various oxazoline based ligands, making significant contributions to the known chemistry of phosphinooxazolines.^{[7] [8]} His current research activities remain focused on ligand development, asymmetric catalysis and catalyst screening.

Professional appointments

• Scientific staff member, ETH Zürich, 1980–1986
• Privatdozent (lecturer), ETH Zürich, 1987–1990
• Associate professor, University of Basel, 1990–1993
• Professor of organic chemistry, University of Basel, 1993–1995
• Head of the Homogeneous Catalysis Section, Max Planck Institute for Coal Research, 1995–1998
• Professor of chemistry, University of Basel, 1999–2015
• Professor emeritus, University of Basel, 2015–present

Awards

• Werner Prize of the Swiss Chemical Society, 1989
• Wilhelm Manchot Research Professorship, TU München, 2002
• Horst-Pracejus-Prize of the German Chemical Society, 2003
• Prelog Medal of the ETH Zürich, 2003
• Ryoji Noyori Prize, The Society of Synthetic Organic Chemistry, Japan, 2008
• Heilbronner-Hückel Lecturer, Swiss Chemical Society and German Chemical Society, 2011
• Member of The German Academy of Sciences "Leopoldina", 2011
• Yamada-Koga Prize, Japan Research Foundation of Optically Active Compounds, 2011
• President of the Bürgenstock conference, 2012
• Chirality Medal, (2016)

Notes and References

1. Pfaltz. Andreas. From Corrin Chemistry to Asymmetric Catalysis - A Personal Account. Synlett. 1999. 1999. S1. 835–842. 10.1055/s-1999-3122.
2. Helmchen. Günter. Andreas Pfaltz: on the Occasion of his 60th Birthday. Advanced Synthesis & Catalysis. 5 May 2008. 350. 7–8. 951–952. 10.1002/adsc.200800113. free.
3. Rasetti. Vittorio. Hilpert, Kurt. Fässler, Alexander. Pfaltz, Andreas. Eschenmoser, Albert. The Dihydrocorphinol→ Corrin Ring Contraction: A Potentially Biomimetic Mode of Formation of the Corrin Structure. Angewandte Chemie International Edition in English. 1 December 1981. 20. 12. 1058–1060. 10.1002/anie.198110581.
4. Pfaltz. Andreas. Jaun, Bernhard. Fassler, Alexander. Eschenmoser, Albert. Jaenchen, Rolf. Gilles, Hans Harald. Diekert, Gabriele. Thauer, Rudolf K.. Zur Kenntnis des Faktors F430 aus methanogenen Bakterien: Struktur des porphinoiden Ligandsystems. Helvetica Chimica Acta. 5 May 1982. 65. 3. 828–865. 10.1002/hlca.19820650320.
5. Fritschi. Hugo. Leutenegger, Urs. Pfaltz, Andreas. Chiral Copper-Semicorrin Complexes as Enantioselective Catalysts for the Cyclopropanation of Olefins by Diazo Compounds. Angewandte Chemie International Edition in English. 1 November 1986. 25. 11. 1005–1006. 10.1002/anie.198610051.
6. Pfaltz. Andreas. Chiral semicorrins and related nitrogen heterocycles as ligands in asymmetric catalysis. Accounts of Chemical Research. 1 June 1993. 26. 6. 339–345. 10.1021/ar00030a007.
7. Helmchen. Günter. Pfaltz, Andreas. PhosphinooxazolinesA New Class of Versatile, Modular P,N-Ligands for Asymmetric Catalysis. Accounts of Chemical Research. 33. 6. 336–345. 10.1021/ar9900865. 10891051. 2000.
8. von Matt. Peter. Pfaltz, Andreas. Chiral Phosphinoaryldihydrooxazoles as Ligands in Asymmetric Catalysis: Pd-Catalyzed Allylic Substitution. Angewandte Chemie International Edition in English. 1 April 1993. 32. 4. 566–568. 10.1002/anie.199305661.