Andreas Dräger Explained

Andreas Dräger
Birth Date:20 September 1980
Birth Place:Wippra, East Germany
Thesis Title:Computational Modeling of Biochemical Networks
Thesis Url:http://www.dr.hut-verlag.de/978-3-86853-850-2.html
Thesis Year:2011
Doctoral Advisor:Andreas Zell
Known For:Mathematical modelling of infectious disease, JSBML
Children:three

Andreas Dräger (pronounced as /de/; born 20 September 1980) is a German bioinformatician who leads the research group for Data Analytics and Bioinformatics at the Martin Luther University of Halle-Wittenberg.

Education

In high school, Dräger was fascinated by computer science and recent advancements in genetics and biotechnology in the late 1990s. When he learned about a new degree program that allowed combining those technologies, he was immediately inspired. So, Dräger studied bioinformatics at the Martin Luther University of Halle-Wittenberg in Halle (Saale) from 2000 to 2006. He worked as an intern for genome sequencing at the Max Planck Institute for Molecular Genetics, Berlin. He prepared his thesis about heavy-metal-resistant bacteria at the microbiology department of the University of Illinois at Chicago. Dräger earned his doctorate at the Center for Bioinformatics in Tübingen (ZBIT), focusing on the dynamic simulation of metabolic networks in a virtual liver. During this time, he worked as a visiting research student for software engineering at Keio University in Yokohama in 2010. After returning from Japan, the Faculty of Science of the University of Tübingen honored his thesis with the 2011 dissertation award.[1]

Career

In early 2011, Dräger received funding for an independent research project as a postdoctoral junior group leader. In 2013, he undertook another two-year postdoc program as a Marie-Curie research scholar in La Jolla. He worked in the Systems Biology Research Group at the UCSD (the University of California, San Diego). Upon returning to Tübingen in 2015, he founded an independent research group at the university. In 2018 he was appointed as junior professor for Computational Systems Biology of Infections and Antimicrobial-Resistant Pathogens within Tübingen's newly established interfaculty Institute for Bioinformatics and Medical Informatics (IBMI). His research group belonged to Tübingen's Cluster of Excellence, "Controlling Microbes to Fight Infections" (CMFI). In February 2024, Dräger was appointed as a university professor and has since held the chair of data analytics and bioinformatics at the Martin Luther University of Halle-Wittenberg,[2] while his group remains part of the German National Center for Infection Research (DZIF) at the University of Tübingen.

Research

Andreas Dräger's research focuses on mathematical models of the metabolic mechanisms behind antibiotic resistance. The central aspect of his research group is the human microbiome living within the airways from the nasal cavities to the lung. Dräger aims to identify new ways to combat life-threatening bacterial[3] [4] and viral infections.[5] [6] Hospital-acquired infections of the respiratory tract have the highest priority of the effort because this often involves germs with multi-resistance against antibiotic treatment. Particularly harmful bacteria in this habitat include Pseudomonas aeruginosa[7] [4] and Staphylococcus aureus.[3] Another research area involves risk groups, such as cystic fibrosis patients. Applying metabolic network modeling for this endeavor requires a comprehensive understanding of the underlying processes of mutual interactions between pathogens, commensal bacteria, and their host.[8] [9]

This work also requires developing specialized software to create, analyze, and share computer models in systems biology in general. For this reason, the group is also actively involved in several standardization efforts in systems biology[10] that are part of the initiatives by the Computational Modeling in Biology Network of international researchers.Dräger sees improved interoperability and reuse of the developed computer models according to the principles of FAIR data (findable, accessible, interoperable, and reusable) as a prerequisite for the reliable implementation of computer simulation in biology.[11] To this end, Dräger and his group develop scientific open-source software, such as JSBML or SBSCL.[12] In 2015, the scientific community elected him as an editor for developing the systems biology file format SBML and in 2018 as an editor for the graphical modeling language SBGN.[13] In 2016, Dräger was one of the founders of the annual community meeting with a special interest in systems modeling (SysMod)[14] within the International Society of Computational Biology (ISCB), where he served as the de facto chairman from 2018 until he stepped down in 2022.[15]

During the COVID-19 pandemic, Dräger's work regarding computational modeling of SARS-CoV-2 within human cells[16] [17] raised international interest[18] [19] [20] [21] [22] [23] [24] because it predicted potentially exploitable targets for drug development. One of those is the human enzyme guanylate kinase. Dräger's ongoing work on this topic focuses on pandemic preparedness.[25]

Commitment and Volunteering

For over three years, he offered a course in bioinformatics and systems biology for high school students at the "Otto-Hahn" high school in Nagold, including mentorship in the Youth Researches competition.[26]

External links

Notes and References

  1. News: Zentrale Promotionsfeier der Universität Tübingen. Central graduation ceremony of the University of Tübingen. German. Newsletter Uni Tübingen aktuell Nr. 4/2011: Termine und Veranstaltungen. 2011-07-16. University of Tübingen.
  2. Martin Luther University Halle-Wittenberg . Martin Luther University Halle-Wittenberg . 2024-03-27 . 2024 . Neue Professorinnen und Professoren an der Universität Halle . live . 2024-08-08 . Neue Professorinnen und Professoren an der Universität Halle . Halle (Saale) . German.
  3. Renz . Alina. Dräger . Andreas. Andreas Dräger. 2021. Curating and Comparing 114 Strain-Specific Genome-Scale Metabolic Models of Staphylococcus aureus. npj Systems Biology and Applications. 7. 1. 30. 10.1038/s41540-021-00188-4. 8241996. 34188046. 233598683.
  4. Payne . Dawson D.. Renz . Alina. Dunphy . Laura J.. Lewis . Taylor. Dräger . Andreas. Andreas Dräger. Papin . Jason A.. 2021. An updated genome-scale metabolic network reconstruction of Pseudomonas aeruginosa PA14 to characterize mucin-driven shifts in bacterial metabolism. npj Systems Biology and Applications. 7. 1. 37. 10.1038/s41540-021-00198-2. 8501023. 34625561. 232224404.
  5. Bernardes . Joana P.. Mishra . Neha. Tran . Florian. Bahmer . Thomas. Best . Lena. Blase . Johanna I.. Bordoni . Dora. Franzenburg . Jeanette. Geisen . Ulf. Josephs-Spaulding . Jonathan. Köhler . Philipp. Künstner . Axel. Rosati . Elisa. Aschenbrenner . Anna C.. Bacher . Petra. Baran . Nathan. Boysen . Teide. Brandt . Burkhard. Bruse . Niklas. Dörr . Jonathan. Dräger . Andreas. Andreas Dräger. Elke . Gunnar. Ellinghaus . David. Fischer . Julia. Forster . Michael. Franke . Andre. Franzenburg . Sören. Frey . Norbert. Friedrichs . Anette. Fuß . Janina. Glück . Andreas. Hamm . Jacob. Hinrichsen . Finn. Hoeppner . Marc P.. Imm . Simon. Juenker . Ralf. Kaiser . Sina. Kan . Ying H.. Knoll . Rainer. Lange . Christoph. Laue . Georg. Lier . Clemes. Lindner . Matthias. Marinos . Georgios. Markewitz . Robert. Nattermann . Jacob. Noth . Rainer. Pickkers . Peter. Rabe . Klaus F.. Renz . Alina. Roecken . Christoph. Rupp . Jan. Schaffarzyk . Annika. Scheffold . Alexander. Schulte-Schrepping . Jonas. Schunck . Domagoj. Skowasch . Dirk. Ulas . Thomas. Wandinger . Klaus-Peter. Wittig . Michael. Zimmermann . Johannes. Busch . Hauke. Hoyer . Bimba F.. Kaleta . Christoph. Heyckendorf . Jan. Kox . Matthijs. Rybniker . Jan. Schreiber . Stefan. Schultze . Joachim. Rosenstiel . Philip. Banovich . Nicholas E.. Desai . Tushar. Eickelberg . Oliver. Haniffa . Muzlifa. Horvath . Peter. Kropski . Jonathan A.. Lafyatis . Robert. Lundeberg . Joakim. Meyer . Kerstin. Nawijn . Martijn C.. Nikolic . Marko. Ordovas Montanes . Jose. Pe'er . Dana. Tata . Purushothama Rao. Rawlins . Emma. Regev . Aviv. Reyfman . Paul. Samakovlis . Christos. Schultze . Joachim. Shalek . Alex. Shepherd . Douglas. Spence . Jason. Teichmann . Sarah. Theis . Fabian. Tsankov . Alexander. van den Berge . Maarten. von Papen . Michael. Whitsett . Jeffrey. Zaragosi . Laure Emmanuelle. Angelov . Angel. Bals . Robert. Bartholomäus . Alexander. Becker . Anke. Bezdan . Daniela. Bonifacio . Ezio. Bork . Peer. Clavel . Thomas. Colme-Tatche . Maria. Diefenbach . Andreas. Dilthey . Alexander. Fischer . Nicole. Förstner . Konrad. Frick . Julia Stefanie. Gagneur . Julien. Goesmann . Alexander. Hain . Torsten. Hummel . Michael. Janssen . Stefan. Kalinowski . Jörn. Kallies . René. Kehr . Birte. Keller . Andreas. Kim-Hellmuth . Sarah. Klein . Christoph. Kohlbacher . Oliver. Korbel . Jan O.. Kurth . Ingo. Landthaler . Markus. Li . Yang. Ludwig . Kerstin. Makarewicz . Oliwia. Marz . Manja. McHardy . Alice. Mertes . Christian. Nöthen . Markus. Nürnberg . Peter. Ohler . Uwe. Ossowski . Stephan. Overmann . Jörg. Peter . Silke. Pfeffer . Klaus. Poetsch . Anna R.. Pühler . Alfred. Rajewsky . Niklaus. Ralser . Markus. Rieß . Olaf. Ripke . Stephan. Nunes da Rocha . Ulisses. Saliba . Antoine Emmanuel. Sander . Leif Erik. Sawitzki . Birgit. Schiffer . Philipp. Schulte . Eva Christina. Sczyrba . Alexander. Stegle . Oliver. Stoye . Jens. Vehreschild . Janne. Vogel . Jörg. Kleist . Max von. Walker . Andreas. Walter . Jörn. Wieczorek . Dagmar. Ziebuhr . John. 2020. Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells and plasmablasts as hallmarks of severe COVID-19 trajectories. Immunity. 53. 6. 1296–1314.e9. 10.1016/j.immuni.2020.11.017. 1074-7613. 7689306. 33296687. 227163641.
  6. Ostaszewski . Marek. Niarakis . Anna. Mazein . Alexander. Kuperstein . Inna. Phair . Robert. Orta-Resendiz . Aurelio. Singh . Vidisha. Aghamiri . Sara Sadat. Acencio . Marcio Luis. Glaab . Enrico. Ruepp . Andreas. Fobo . Gisela. Montrone . Corinna. Brauner . Barbara. Frishman . Goar. Monraz Gómez . Luis Cristóbal. Somers . Julia. Hoch . Matti. Gupta . Shailendra Kumar. Scheel . Julia. Borlinghaus . Hanna. Czauderna . Tobias. Schreiber . Falk. Montagud . Arnau. Ponce de Leon . Miguel. Funahashi . Akira. Hiki . Yusuke. Hiroi . Noriko. Yamada . Takahiro G.. Dräger . Andreas. Andreas Dräger. Renz . Alina. Naveez . Muhammad. Bocskei . Zsolt. Messina . Francesco. Börnigen . Daniela. Fergusson . Liam. Conti . Marta. Rameil . Marius. Nakonecnij . Vanessa. Vanhoefer . Jakob. Schmiester . Leonard. Wang . Muying. Ackerman . Emily E.. Shoemaker . Jason E.. Zucker . Jeremy. Oxford . Kristie L.. Teuton . Jeremy and. Kocakaya . Ebru. Summak . Gökçe Yağmur. Hanspers . Kristina. Kutmon . Martina. Coort . Susan. Eijssen . Lars. Ehrhart . Friederike. Devasahayam Arokia Balaya . Rex. Slenter . Denise. Martens . Marvin. Haw . Robin. Jassal . Bijay. Matthews . Lisa. Orlic-Milacic . Marija. Senff-Ribeiro . Andrea. Rothfels . Karen. Shamovsky . Veronica and. Stephan . Ralf. Sevilla . Cristoffer. Varusai . Thawfeek Mohamed. Ravel . Jean-Marie and. Fraser . Rupsha. Ortseifen . Vera. Marchesi . Silvia. Gawron . Piotr. Smula . Ewa and. Heirendt . Laurent. Satagopam . Venkata. Wu . Guanming. Riutta . Anders. Golebiewski . Martin. Owen . Stuart. Goble . Carole. Hu . Xiaoming. Overall . Rupert. Maier . Dieter. Bauch . Angela. Bachman . John A.. Gyori . Benjamin M.. Vega . Carlos and. Grouès . Valentin. Vazquez . Miguel. Porras . Pablo. Licata . Luana. Iannuccelli . Marta. Sacco . Francesca. Turei . Denes. Luna . Augustin. Babur . Ozgun. Soliman . Sylvain. Valdeolivas . Alberto. Esteban-Medina . Marina. 1. Peña-Chilet . Maria and. Helikar . Tomáš. Puniya . Bhanwar Lal. Nesterova . Anastasia. Yuryev . Anton. de Waard . Anita. Modos . Dezso. Treveil . Agatha. Olbei . Marton Laszlo. De Meulder . Bertrand. Naldi . Aurélien. Dugourd . Aurélien. Noël . Vincent. Calzone . Laurence. Sander . Chris. Demir . Emek. Korcsmaros . Tamas. Freeman . Tom C.. Augé . Franck. Beckmann . Jacques S.. Hasenauer . Jan. Wolkenhauer . Olaf. Willighagen . Egon L.. Pico . Alexander R.. Evelo . Chris. Gillespie . Marc. Stein . Lincoln D.. Hermjakob . Henning. D'Eustachio . Peter. Saez-Rodriguez . Julio. Dopazo . Joaquin. Valencia . Alfonso. Kitano . Hiroaki. Barillot . Emmanuel. Auffray . Charles. Balling . Rudi. Schneider . Reinhard. the COVID-19 Disease Map Community. 2021. COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms. Molecular Systems Biology. 17. 10. e10387. 10.15252/msb.202110387. 8524328. 34664389. 239027089.
  7. Sanjeev . Dahal. Alina . Renz. Andreas . Dräger. Laurence . Yang. Andreas Dräger. 2023. Genome-scale model of Pseudomonas aeruginosa metabolism unveils virulence and drug potentiation. Communications Biology. 6. 1. 165. 10.1038/s42003-023-04540-8. 9918512. 36765199. 256702200. free.
  8. Alina . Renz. Lina . Widerspick. Andreas . Dräger. Andreas Dräger. 2021. First Genome-Scale Metabolic Model of Dolosigranulum pigrum Confirms Multiple Auxotrophies. Metabolites. 11. 4. 232. 10.3390/metabo11040232. 8069353. 33918864. 233395707. free.
  9. Elizabeth . Brunk. Swagatika . Sahoo. Daniel C. . Zielinski. Ali . Altunkaya. Andreas . Dräger. Andreas Dräger. Nathan . Mih. Francesco . Gatto. Avlant . Nilsson. German Andres . Preciat Gonzalez. Maike Kathrin . Aurich. Andreas . Prlić. Anand . Sastry. Anna D. . Danielsdóttir. Almut . Heinken. Alberto . Noronha. Peter W. . Rose. Stephen K. . Burley. Ronan M. T. . Fleming. Jens . Nielsen. Ines . Thiele. Bernhard O. . Palsson. 2018. Recon3D enables a three-dimensional view of gene variation in human metabolism. Nature Biotechnology. 36. 3. 272–281. 10.1038/nbt.4072. 5840010. 29457794. 210902494.
  10. Book: 10.1016/B978-0-12-816077-0.00001-7. Overview: Standards for Modeling in Systems Medicine. Systems Medicine. 2021. Dräger . Andreas. Andreas Dräger. Waltemath. Dagmar. 345–353. 978-0-12-816078-7. 224975951.
  11. Dräger . Andreas. Andreas Dräger. 2014. Improving collaboration by standardization efforts in systems biology. Frontiers in Bioengineering and Biotechnology. 2. 61. 61. 10.3389/fbioe.2014.00061. 4259112. 25538939. 16722945. free.
  12. Panchiwala . Hemil. Shah . Shalin. Planatscher . Hannes. Zakharchuk . Mykola. König . Matthias. Dräger . Andreas. Andreas Dräger. 2022. The Systems Biology Simulation Core Library. Bioinformatics. 38 . 3. 864–865. 10.1093/bioinformatics/btab669. 8756180. 34554191. 230546045.
  13. Book: 10.1016/B978-0-12-801238-3.11515-6. The Systems Biology Graphical Notation: Current Status and Applications in Systems Medicine. Systems Medicine. 2021. Touré . Vasundra. Dräger . Andreas. Andreas Dräger. Luna . Augustin. Dogrusoz . Ugur. Rougny . Adrien. 372–381 . 978-0-12-816078-7. 213385953.
  14. Dräger . Andreas. Andreas Dräger. Helikar . Tomáš. Barberis . Matteo. Birtwistle . Marc. Calzone . Laurence. Chaouiya . Claudine. Hasenauer . Jan. Karr . Jonathan R.. Niarakis . Anna. Rodríguez Martínez . María. Saez-Rodriguez . Julio. Thakar . Juilee. 2021. SysMod: the ISCB community for data-driven computational modelling and multi-scale analysis of biological systems. Bioinformatics. 37. 21. 3702–3706. 10.1093/bioinformatics/btab229. 8570808. 34179955. 234620344.
  15. Niarakis . Anna. Thakar . Juilee. Barberis . Matteo. Rodríguez Martínez . María. Helikar . Tomáš. Birtwistle . Marc. Chaouiya . Claudine. Calzone . Laurence. Dräger . Andreas. Andreas Dräger. 2022. Computational modelling in health and disease. Highlights of the 6th annual SysMod meeting. Bioinformatics. 38. 21. 4990–4993. 10.1093/bioinformatics/btac609.
  16. Renz . Alina. Widerspick . Lina. Dräger . Andreas. Andreas Dräger. 2020. FBA reveals guanylate kinase as a potential target for antiviral therapies against SARS-CoV-2. Bioinformatics. 36. Suppl 2. i813–i821. 10.1093/bioinformatics/btaa813. 7773487. 33381848. 229929774.
  17. Renz . Alina. Widerspick . Lina. Dräger . Andreas. Andreas Dräger. 2021. Genome-Scale Metabolic Model of Infection with SARS-CoV-2 Mutants Confirms Guanylate Kinase as Robust Potential Antiviral Target. Genes. 12. 6. 796. 10.3390/genes12060796. 8225150. 34073716. 235300463. free.
  18. Wittig . Frank. odysso – Wissen im SWR. Wo bleiben die Medikamente?. Where are the drugs?. German. SWR Fernsehen. 2021-03-18.
  19. Augustin . Birgit. Visite. Corona: Wie wirksam sind neue Medikamente gegen das Virus?. Corona: How effective are new drugs against the virus?. German. Norddeutscher Rundfunk. 2021-02-03.
  20. Petrunova . Tsvetelina. Тази неделя. Ексклузивно: Първа стъпка към откриването лекарство срещу COVID-19. Exclusive: First step towards discovering a drug against COVID-19. Bulgarian. 2021-01-17. bTV (Bulgaria).
  21. Beremliyski . Nikolay. неделята. СЛАБОТО МЯСТО НА COVID-19: Близо ли сме до победата над заразата?. THE COVID-19 WEAKNESS POINT: Are we close to beating the plague?. Bulgarian. 2021-01-17. Nova (Bulgarian TV channel).
  22. News: Ученые РФ и ФРГ нашли способы уничтожать COVID-19. Scientists from Russia and Germany have found ways to destroy COVID-19. Russian. Смотрим. 2021-11-01. Russia-24.
  23. News: Hannemann . Cornelia. Entdeckung könnte Weg zu Corona-Medikament ebnen. Discovery could pave way to Corona drug. German. Wissen. 2021-01-10. n-tv.
  24. News: Priese . Anna. Neuer Ansatz für Corona-Therapie an Tübinger Uni. New approach for corona therapy at Tübingen University. German. SWR Aktuell. 2021-01-09. SWR Fernsehen.
  25. Leonidou . Nantia. Renz . Alina. Mostolizadeh . Reihaneh. Dräger . Andreas. Andreas Dräger. 2023. New workflow predicts drug targets against SARS-CoV-2 via metabolic changes in infected cells. PLOS Computational Biology. 19. 3. e1010903. 10.1371/journal.pcbi.1010903. 10035753. 36952396. 257715107. free.
  26. News: Mit Stolz präsentieren sie erste Ergebnisse. They proudly present their first results. German. 2021-07-21. Schwarzwälder Bote. Schwarzwälder Bote Mediengesellschaft mbH.

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