Andrea Musacchio Explained

Andrea Musacchio
Birth Name:Andrea Musacchio
Birth Date:11 July 1964
Birth Place:Rome, Italy
Nationality:Italian
Fields:Crystallography
Workplaces:Harvard Medical School, European Institute of Oncology, Max Planck Institute for Molecular Physiology
Alma Mater:University of Rome Tor Vergata, European Molecular Biology Laboratory
Doctoral Advisor:Matti Saraste
Academic Advisors:Gianni Cesareni

Andrea Musacchio (born July 11, 1964)[1] is an Italian structural biologist. He is Max Planck director at the Institute of Molecular Physiology in Dortmund. He is also Honorary Professor at the Center for Medical Biotechnology at the University of Duisburg-Essen. He was named European Molecular Biology Organization member in 2009.[2]

Education and career

Musacchio received a Laurea in Biology from the University of Rome Tor Vergata summa cum laude in 1990, and earned his Ph.D., summa cum laude, from the Heidelberg University in 1995 working at the European Molecular Biology Laboratory. For his postdoctoral studies he joined Stephen C. Harrison laboratory at the Harvard Medical School in Boston. In 1999 he returned to Italy to found his laboratory at the European Institute of Oncology in Milan, where he started working on mechanisms of cell division. He was a European Molecular Biology Organization Young Investigator from 2000-2004. Musacchio moved to Dortmund in 2011 to direct the Department of Mechanistic Cell Biology at the Max Planck Institute for Molecular Physiology[3]

Research

Musacchio approached structural biology during his Ph.D., contributing to the determination of the first crystallographic structures of the SH3[4] and PH[5] domains. During his post-doctoral training, he was involved in the determination of the clathrin triskelion structure,[6] one of the first studies combining X-ray crystallography and electron microscopy.As an independent scientist, his interests focused on the understanding of the molecular basis of mitosis, with emphasis on the spindle assembly checkpoint. Since the early days, Musacchio's lab adopted a multi-disciplinary approach merging structural biology, biochemistry and cellular biology, this way gaining comprehensive views on protein functions in living cells.[7] He is best known for his work on Mad1/Mad2 complexes,[8] [9] which led to the formulation of the template model,[10] and for his contributions to the understanding of the role of the kinase Aurora B, Mps1 and Haspin in mitosis.[11] [12] [13] [14] In 2008, the structure of the Ndc80 complex [15] set the foundation of a new line of his investigations on kinetochore assembly and attachment to microtubules[16] [17] [18]

Personal life

Musacchio spent his childhood in Rome, where he grew to be a strong supporter of A.S. Roma. He has started embracing Borussia Dortmund.

He is married and father of two boys.

External links

Notes and References

  1. Web site: Musacchio, Andrea . 2024-01-12 . www.mpg.de . en.
  2. http://www.ifom-ieo-campus.it/press/download/Press_release_New_Members_layout_14_10_09.pdf 2009 EMBO Press Release
  3. Musacchio A. . Andrea Musacchio . Current Biology . 22 . 14 . R552–R554 . 2012 . 23012739 . 10.1016/j.cub.2012.06.024. free .
  4. Musacchio. A. Noble. M. Pauptit. R. Wierenga. R. Saraste. M. Crystal structure of a Src-homology 3 (SH3) domain.. Nature. Oct 29, 1992. 359. 6398. 851–5. 1279434. 10.1038/359851a0. 1992Natur.359..851M. 4254768.
  5. Macias. MJ. Musacchio. A. Ponstingl. H. Nilges. M. Saraste. M. Oschkinat. H. Structure of the pleckstrin homology domain from beta-spectrin.. Nature. Jun 23, 1994. 369. 6482. 675–7. 8208297. 10.1038/369675a0. 1994Natur.369..675M. 4358947.
  6. Musacchio. A. Smith. CJ. Roseman. AM. Harrison. SC. Kirchhausen. T. Pearse. BM. Functional Organization of Clathrin in Coats: Combining Electron Cryomicroscopy and X-Ray Crystallography. Molecular Cell. Jun 1999. 3. 6. 761–70. 10394364. 10.1016/S1097-2765(01)80008-3. free.
  7. Nasmyth. K. How do so few control so many?. Cell. Mar 25, 2005. 120. 6. 739–46. 15797376. 10.1016/j.cell.2005.03.006. 18831437. free.
  8. Sironi. L. Mapelli. M. Knapp. S. De Antoni. A. Jeang. KT. Musacchio. A. Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint.. The EMBO Journal. May 15, 2002. 21. 10. 2496–506. 12006501. 10.1093/emboj/21.10.2496. 126000.
  9. Mapelli. M. Massimiliano. L. Santaguida. S. Musacchio. A. The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint.. Cell. Nov 16, 2007. 131. 4. 730–43. 18022367. 10.1016/j.cell.2007.08.049. 2434/65744. 17345925. free.
  10. De Antoni. A. Pearson. CG. Cimini. D. Canman. JC. Sala. V. Nezi. L. Mapelli. M. Sironi. L. Faretta. M. Salmon. ED. Musacchio. A. The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint.. Current Biology. Feb 8, 2005. 15. 3. 214–25. 15694304. 10.1016/j.cub.2005.01.038. 3224122. free.
  11. De Antoni. A. Maffini. S. Knapp. S. Musacchio. A. Santaguida. S. A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B.. The Journal of Cell Biology. Oct 15, 2012. 199. 2. 269–84. 23071153. 10.1083/jcb.201205119. 3471222.
  12. Santaguida. S. Vernieri. C. Villa. F. Ciliberto. A. Musacchio. A. Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction.. The EMBO Journal. Apr 20, 2011. 30. 8. 1508–19. 21407176. 10.1038/emboj.2011.70. 3102279.
  13. Santaguida. S. Tighe. A. D'Alise. AM. Taylor. SS. Musacchio. A. Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine.. The Journal of Cell Biology. Jul 12, 2010. 190. 1. 73–87. 20624901. 10.1083/jcb.201001036. 2911657.
  14. Sessa. F. Mapelli. M. Ciferri. C. Tarricone. C. Areces. LB. Schneider. TR. Stukenberg. PT. Musacchio. A. Mechanism of Aurora B activation by INCENP and inhibition by hesperadin.. Molecular Cell. Apr 29, 2005. 18. 3. 379–91. 15866179. 10.1016/j.molcel.2005.03.031. free.
  15. Ciferri. C. Pasqualato. S. Screpanti. E. Varetti. G. Santaguida. S. Dos Reis. G. Maiolica. A. Polka. J. De Luca. JG. De Wulf. P. Salek. M. Rappsilber. J. Juri Rappsilber. Moores. CA. Salmon. ED. Musacchio. A. Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex.. Cell. May 2, 2008. 133. 3. 427–39. 18455984. 10.1016/j.cell.2008.03.020. 4754795.
  16. Santaguida. S. Musacchio. A. The life and miracles of kinetochores.. The EMBO Journal. Sep 2, 2009. 28. 17. 2511–31. 19629042. 10.1038/emboj.2009.173. 2722247.
  17. Petrovic. A. Mosalaganti. S. Keller. J. Mattiuzzo. M. Overlack. K. Krenn. V. De Antoni. A. Wohlgemuth. S. Cecatiello. V. Pasqualato. S. Raunser. S. Musacchio. A. Modular assembly of RWD domains on the Mis12 complex underlies outer kinetochore organization.. Molecular Cell. Feb 20, 2014. 53. 4. 591–605. 24530301. 10.1016/j.molcel.2014.01.019. free. 10281/397721. free.
  18. Basilico. F. Maffini. S. Weir. JR. Prumbaum. D. Rojas. AM. Zimniak. T. De Antoni. A. Jeganethan. S. Voss. B. van Gerwen. S. Krenn. V. Massimiliano. L. Valencia. A. Vetter. IR. Herzog. F. Raunser. S. Pasqualato. S. Musacchio. A. The pseudo GTPase CENP-M drives human kinetochore assembly.. eLife. Jul 8, 2014. 3. e02978. 25006165. 10.7554/elife.02978. 4080450. free.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Andrea Musacchio".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.