André Hoelz Explained

Birth Place:Lüdenscheid, Nordrhine Westalia, Germany
Citizenship:German, American
Fields:Chemistry
Biochemistry
Structural Biology
Cell Biology
Workplaces:Rockefeller University
Alma Mater:University of Freiburg
(Vordiplom, Diplom)
The Rockefeller University
(Ph.D.)
Academic Advisors:Karl Decker
John Kuriyan
Günter Blobel

André Hoelz is a German-American structural cell biologist. Currently, he is the Mary and Charles Ferkel Professor of Chemistry and Biochemistry at the California Institute of Technology (Caltech) and an Investigator of the Howard Hughes Medical Institute.[1] [2] He is best known for his research on the structure and function of the nuclear pore complex and its role in nucleocytoplasmic transport.[3] [4]

Early life and education

André Hoelz completed his undergraduate education at Albert-Ludwig University in Freiburg, Germany, receiving his Vordiplom in Chemistry in 1993 and his Diplom in Chemistry and Biochemistry in 1997. He then pursued graduate studies at The Rockefeller University, working with John Kuriyan on the regulation of protein kinases, and earned his Ph.D. in Biochemistry and Structural Biology in 2004. He remained at Rockefeller to establish a structural biology group in Günter Blobel's laboratory, where he initiated the comprehensive structural and functional characterization of the nuclear pore complex. In 2010, he moved to the California Institute of Technology, where he has been since.[5]

Research

Hoelz’s research focuses on the structural cell biology of nucleocytoplasmic transport, with a particular emphasis on the structural characterization of the nuclear pore complex, a large channel embedded in the nuclear envelope that mediates the regulated bi-directional exchange of macromolecules between the nucleus and cytoplasm.[6] His laboratory has made significant contributions to understanding the nuclear pore complex's structural architecture and its role in regulating molecular transport.[7] Hoelz has used techniques such as X-ray crystallography and cryo-electron microscopy to uncover the molecular details of the nuclear pore complex, with implications for diseases linked to defects in nuclear transport, including cancer and neurodegenerative disorders.[8] His lab is also known for its research on mRNA export, specifically how messenger RNA is transported from the nucleus to the cytoplasm, a crucial step in gene expression and the central dogma.[9]

Grants and unding

Hoelz’s research has been supported by several major grants, including funding from the Howard Hughes Medical Institute and the National Institutes of Health.[10]

Selected publications

Hoelz has authored numerous high-impact research papers in leading scientific journals, covering topics related to structural cell biology of nucleocytoplasmic transport.[11] [12] [13] [14] [15] [16] Additionally, he has contributed to our mechanistic understanding of various important enzymes, including protein kinases, acetyl transferases, deacetylases, demethylases, and oxidases.[17] [18] [19] [20] [21]

Awards

Hoelz was a Faculty Scholar of the Howard Hughes Medical Institute from 2016 to 2021,[22] [23] an Investigator at the Heritage Medical Research Institute at Caltech from 2015 to 2021,[24] and has received numerous scientific awards, including the Camille Dreyfus Teacher-Scholar Award of the Camille & Henry Dreyfus Foundation in 2015,[25] the Kimmel Scholar Award from the Sidney Kimmel Foundation for Cancer Research in 2012,[26] the 54th Mallinckrodt Scholar Award of the Edward Mallinckrodt, Jr. Foundation in 2011,[27] the Albert Wyrick V Scholar Award from The V Foundation for Cancer Research in 2010,[28] the Burroughs Wellcome Fund Pre-Doctoral Fellowship in the Interfaces of Science Program in 1999, and the Prize of the “Fonds der Chemischen Industrie” for academic excellence in 1991. The structural work on the nuclear pore complex has been awarded "Biological Structure of the Year" in 2016 by Chemical & Engineering News,[29] and research highlights by the Advanced Photon Source at the Argonne National Laboratory in 2016 and 2022,[30] [31] Stanford Synchrotron Radiation Lightsource in 2016 and 2022,[32] [33] and National Synchrotron Light Source II at the Brookhaven National Laboratory in 2018.[34]

Notes and References

  1. Web site: André Hoelz - Division of Chemistry and Chemical Engineering . November 11, 2024 . cce.caltech.edu.
  2. Web site: HHMI Invests over $300 Million in 26 New Investigators . HHMI.
  3. Lin . Daniel H. . Hoelz . André . June 20, 2019 . The Structure of the Nuclear Pore Complex (An Update) . Annual Review of Biochemistry . 88 . 725–783 . 10.1146/annurev-biochem-062917-011901 . 1545-4509 . 6588426 . 30883195.
  4. Hoelz . André . Debler . Erik W. . Blobel . Günter . 2011 . The structure of the nuclear pore complex . Annual Review of Biochemistry . 80 . 613–643 . 10.1146/annurev-biochem-060109-151030 . 1545-4509 . 21495847.
  5. Web site: André Hoelz - Division of Chemistry and Chemical Engineering . November 11, 2024 . cce.caltech.edu.
  6. Hoelz . André . Debler . Erik W. . Blobel . Günter . 2011 . The structure of the nuclear pore complex . Annual Review of Biochemistry . 80 . 613–643 . 10.1146/annurev-biochem-060109-151030 . 1545-4509 . 21495847.
  7. Hsia . Kuo-Chiang . Stavropoulos . Pete . Blobel . Günter . Hoelz . André . December 28, 2007 . Architecture of a coat for the nuclear pore membrane . Cell . 131 . 7 . 1313–1326 . 10.1016/j.cell.2007.11.038 . 0092-8674 . 2213454 . 18160040.
  8. Petrovic . Stefan . Mobbs . George W. . Bley . Christopher J. . Nie . Si . Patke . Alina . Hoelz . André . December 1, 2022 . Structure and Function of the Nuclear Pore Complex . Cold Spring Harbor Perspectives in Biology . 14 . 12 . a041264 . 10.1101/cshperspect.a041264 . 1943-0264 . 9732903 . 36096637.
  9. Lin . Daniel H. . Correia . Ana R. . Cai . Sarah W. . Huber . Ferdinand M. . Jette . Claudia A. . Hoelz . André . June 13, 2018 . Structural and functional analysis of mRNA export regulation by the nuclear pore complex . Nature Communications . 9 . 1 . 2319 . 10.1038/s41467-018-04459-3 . 2041-1723 . 5998080 . 29899397.
  10. Web site: HHMI Invests Over $300 Million in 26 New Investigators . November 11, 2024 . www.hhmi.org . en.
  11. Melcák . Ivo . Hoelz . André . Blobel . Günter . March 23, 2007 . Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding . Science (New York, N.Y.) . 315 . 5819 . 1729–1732 . 10.1126/science.1135730 . 1095-9203 . 17379812.
  12. Stuwe . Tobias . Correia . Ana R. . Lin . Daniel H. . Paduch . Marcin . Lu . Vincent T. . Kossiakoff . Anthony A. . Hoelz . André . March 6, 2015 . Nuclear pores. Architecture of the nuclear pore complex coat . Science (New York, N.Y.) . 347 . 6226 . 1148–1152 . 10.1126/science.aaa4136 . 1095-9203 . 5180592 . 25745173.
  13. Stuwe . Tobias . Bley . Christopher J. . Thierbach . Karsten . Petrovic . Stefan . Schilbach . Sandra . Mayo . Daniel J. . Perriches . Thibaud . Rundlet . Emily J. . Jeon . Young E. . Collins . Leslie N. . Huber . Ferdinand M. . Lin . Daniel H. . Paduch . Marcin . Koide . Akiko . Lu . Vincent . October 2, 2015 . Architecture of the fungal nuclear pore inner ring complex . Science (New York, N.Y.) . 350 . 6256 . 56–64 . 10.1126/science.aac9176 . 1095-9203 . 4826903 . 26316600.
  14. Lin . Daniel H. . Stuwe . Tobias . Schilbach . Sandra . Rundlet . Emily J. . Perriches . Thibaud . Mobbs . George . Fan . Yanbin . Thierbach . Karsten . Huber . Ferdinand M. . Collins . Leslie N. . Davenport . Andrew M. . Jeon . Young E. . Hoelz . André . April 15, 2016 . Architecture of the symmetric core of the nuclear pore . Science (New York, N.Y.) . 352 . 6283 . aaf1015 . 10.1126/science.aaf1015 . 1095-9203 . 5207208 . 27081075.
  15. Bley . Christopher J. . Nie . Si . Mobbs . George W. . Petrovic . Stefan . Gres . Anna T. . Liu . Xiaoyu . Mukherjee . Somnath . Harvey . Sho . Huber . Ferdinand M. . Lin . Daniel H. . Brown . Bonnie . Tang . Aaron W. . Rundlet . Emily J. . Correia . Ana R. . Chen . Shane . June 10, 2022 . Architecture of the cytoplasmic face of the nuclear pore . Science (New York, N.Y.) . 376 . 6598 . eabm9129 . 10.1126/science.abm9129 . 1095-9203 . 9348906 . 35679405.
  16. Petrovic . Stefan . Samanta . Dipanjan . Perriches . Thibaud . Bley . Christopher J. . Thierbach . Karsten . Brown . Bonnie . Nie . Si . Mobbs . George W. . Stevens . Taylor A. . Liu . Xiaoyu . Tomaleri . Giovani Pinton . Schaus . Lucas . Hoelz . André . June 10, 2022 . Architecture of the linker-scaffold in the nuclear pore . Science (New York, N.Y.) . 376 . 6598 . eabm9798 . 10.1126/science.abm9798 . 1095-9203 . 9867570 . 35679425.
  17. Web site: hoelz A - Search Results - PubMed . November 11, 2024 . PubMed . en.
  18. Hoelz . André . Nairn . Angus C. . Kuriyan . John . May 2003. Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II . Molecular Cell . 11 . 5 . 1241–1251 . 10.1016/s1097-2765(03)00171-0 . 1097-2765 . 12769848.
  19. Davenport . Andrew M. . Huber . Ferdinand M. . Hoelz . André . February 6, 2014 . Structural and functional analysis of human SIRT1 . Journal of Molecular Biology . 426 . 3 . 526–541 . 10.1016/j.jmb.2013.10.009 . 1089-8638 . 4211926 . 24120939.
  20. Davenport . Andrew M. . Collins . Leslie N. . Chiu . Hui . Minor . Paul J. . Sternberg . Paul W. . Hoelz . André . July 15, 2014 . Structural and functional characterization of the α-tubulin acetyltransferase MEC-17 . Journal of Molecular Biology . 426 . 14 . 2605–2616 . 10.1016/j.jmb.2014.05.009 . 1089-8638 . 4259157 . 24846647.
  21. Stavropoulos . Pete . Blobel . Günter . Hoelz . André . July 2006. Crystal structure and mechanism of human lysine-specific demethylase-1 . Nature Structural & Molecular Biology . 13 . 7 . 626–632 . 10.1038/nsmb1113 . 1545-9993 . 16799558.
  22. Web site: HHMI 2016 Faculty Scholars .
  23. Web site: Caltech News 2016 Faculty Scholars . September 22, 2016 .
  24. Web site: Caltech News Heritage Investigators . September 10, 2015 .
  25. Web site: Teacher-Scholar .
  26. Web site: Kimmel Scholars .
  27. Web site: Mallinckrodt Scholar .
  28. Web site: V Scholar .
  29. 2016-12-19 . Biological structures of the year . C&EN Global Enterprise . 94 . 49 . 27–27 . 10.1021/cen-09449-cover6.
  30. Web site: Solving the Structure of the Cell's DNA Gatekeeper . 2024-12-04 . www.aps.anl.gov . en.
  31. Web site: Using X-rays to Decode a Complex Piece of Cellular Machinery, Atom by Atom . 2024-12-04 . www.aps.anl.gov . en.
  32. Web site: SSRL Headlines August 2016 . 2024-12-04 . www-ssrl.slac.stanford.edu.
  33. Web site: SSRL Headline News - Vol. 23, No. 1 Jul-Aug 2022 Stanford Synchrotron Radiation Lightsource . 2024-12-04 . www-ssrl.slac.stanford.edu.
  34. Web site: Structure of a Nuclear Pore Complex's "Ticket System" . 2024-12-04 . Brookhaven National Laboratory . en.

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