Anazocine Explained

Anazocine (INN; also known as azabicyclane or CS-307) is an opioid analgesic of the morphan/benzomorphan family developed in the middle 1960s in the United States which was never marketed.^{[1] [2]} It is listed by some sources as a teratogen.^[3]

The structure and properties of several related α- and β-azabicyclane opioids was explored.^[4] Anazocine's chemical and structural relatives include opioid partial agonists, mixed agonist-antagonists, pure agonists, antagonists, and atypical non-opioid analgesics. It was tested in pigeons and in other experiments which contrasted and compared its analgesic effects to those of the phenazepine opioid ethoheptazine and the phenalkoxam open chain opioid propoxyphene,^[5] and pethidine as well.^[6]

See also

• Benzomorphan

Notes and References

1. Book: Macdonald F . Ganellin CR, Triggle DJ . Dictionary of Pharmacological Agents . 22 April 2012 . 1997 . CRC Press . 978-0-412-46630-4 . 146.
2. Kobayashi S, Hasegawa K, Oshima T, Takagi H . The pharmacology of azabicyclane, a new analgesic agent . Toxicology and Applied Pharmacology . 17 . 2 . 344–354 . September 1970 . 5528556 . 10.1016/0041-008X(70)90191-2 .
3. Web site: Teratogens . Radiological and Environmental Management . Purdue University . 2016-03-01 . https://web.archive.org/web/20160215025937/https://www.purdue.edu/ehps/rem/ih/terat.htm . 2016-02-15 . dead .
4. 10.1002/jcc.540050403 . 5 . 4 . Conformational properties of α- and β-azabicyclane opiates. The effect of conformation on pharmacological activity . Journal of Computational Chemistry . 291–298. 1984 . Froimowitz M, Salva P, Hite GJ, Gianutsos G, Suzdak P, Heyman R . 97334125 .
5. Kobayashi S, Hasegawa K, Oshima T, Takagi H . The pharmacology of azabicyclane, a new analgesic agent . Toxicology and Applied Pharmacology . 17 . 2 . 344–354 . September 1970 . 5528556 . 10.1016/0041-008X(70)90191-2 .
6. Leander JD . Effects of propoxyphene, ethoheptazine, and azabicyclane on schedule-controlled responding: attenuation by pentobarbital but not naloxone . Psychopharmacology . 66 . 1 . 19–22 . 1979 . 44372 . 10.1007/BF00431983 . 29627833 .