| Official Name: | Anastácio |
| Settlement Type: | Municipality |
| Pushpin Map: | Brazil |
| Pushpin Map Caption: | Location in Brazil |
| Coordinates: | -20.4839°N -55.8069°W |
| Subdivision Type: | Country |
| Subdivision Name: | Brazil |
| Subdivision Type1: | Region |
| Subdivision Name1: | Central-West |
| Subdivision Type2: | State |
| Subdivision Name2: | Mato Grosso do Sul |
| Subdivision Type3: | Mesoregion |
| Subdivision Type4: | Microregion |
| Subdivision Type5: | Metrop. region |
| Leader Title: | Mayor |
| Area Total Km2: | 2,949 |
| Population Total: | 25,237 |
| Population As Of: | 2020 [1] |
| Population Density Km2: | auto |
| Timezone1: | AMT |
| Utc Offset1: | -4 |
| Postal Code Type: | Postal code |
| Area Code Type: | Area code |
Anastácio is a municipality located in the Brazilian state of Mato Grosso do Sul. Its population was 25,237 (2020) and its area is 2,949 km2.