Anaritide Explained

Anaritide (also known as human atrial natriuretic peptide [102-126])[1] is a synthetic analogue of atrial natriuretic peptide[2] (ANP).

Structure

Anartidine has the following primary structure:[3]

RSSCFGGRMDRIGAQSGLGCNSFRY

or

H-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH

This structure is identical to residues 102-126 of human preproANP.[4] In comparison, active human ANP comprises resides 99-126 of human preproANP.[5]

Medical uses

Anaritide has been investigated as a potential therapy for acute tubular necrosis but was shown not to improve the dialysis-free survival of these patients. It also appears to exacerbate proteinuria and natriuresis in patients with nephrotic syndrome.[6]

Notes and References

  1. Englebach IM, Lappe RW, Hand JM . Bronchoprotective and bronchodilator activity of anaritide (human atrial natriuretic factor [102-126]) infusion in the anesthetized guinea pig . Pulmonary Pharmacology . 1 . 3 . 119–123 . 1988-07-22 . 2980981 . 10.1016/S0952-0600(88)80009-7 .
  2. Allgren RL, Marbury TC, Rahman SN, Weisberg LS, Fenves AZ, Lafayette RA, Sweet RM, Genter FC, Kurnik BR, Conger JD, Sayegh MH . 6 . Anaritide in acute tubular necrosis. Auriculin Anaritide Acute Renal Failure Study Group . The New England Journal of Medicine . 336 . 12 . 828–834 . March 1997 . 9062091 . 10.1056/NEJM199703203361203 . free .
  3. Sato M, Anno I, Yamaguchi M, Iida H, Orii K . Splenic artery aneurysm of the anomalous splenomesenteric trunk: successful treatment by transcatheter embolization using detachable coils . CardioVascular and Interventional Radiology . 29 . 3 . 432–434 . 2006 . 16132382 . 10.1007/s00270-005-0036-x . 37802801 .
  4. Yandle T, Crozier I, Nicholls G, Espiner E, Carne A, Brennan S . Amino acid sequence of atrial natriuretic peptides in human coronary sinus plasma . Biochemical and Biophysical Research Communications . 146 . 2 . 832–839 . July 1987 . 2956952 . 10.1016/0006-291X(87)90606-1 .
  5. Rosenzweig A, Seidman CE . Atrial natriuretic factor and related peptide hormones . Annual Review of Biochemistry . 60 . 229–255 . 1991 . 1652921 . 10.1146/annurev.bi.60.070191.001305 .
  6. Zietse R, Schalekamp MA . Effect of synthetic human atrial natriuretic peptide (102-126) in nephrotic syndrome . Kidney International . 34 . 5 . 717–724 . November 1988 . 2974095 . 10.1038/ki.1988.238 . free .

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