| Amyderýa Nature Reserve | |
| Map: | Turkmenistan |
| Relief: | 1 |
| Location: | Lebap Province,  Turkmenistan |
| Coordinates: | 39.65°N 113°W |
| Area: | 495 km2 |
| Established: | 1982 |
Amyderýa Nature Reserve is a nature reserve (zapovednik) of north-eastern Turkmenistan.
Established in 1982 to protect part of the Amu Darya River, it is located in the north-east of Lebap Province and covers an area of 495 km2.
It also incorporates one sanctuary: