Amthamine Explained

Amthamine is a histamine agonist selective for the H2 subtype.[1] It has been used in vitro and in vivo to study gastric secretion,[2] as well as other functions of the H2 receptor.[3] [4] [5]

Notes and References

  1. 1507209. 1992. Eriks. J. C. Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazoles. Journal of Medicinal Chemistry. 35. 17. 3239–46. Van Der Goot. H. Sterk. G. J. Timmerman. H. 10.1021/jm00095a021.
  2. 10.1007/BF00168540 . Coruzzi G, Timmerman H, Adami M, Bertaccini G . The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion . Naunyn-Schmiedeberg's Arch Pharmacol . 348 . 1 . 77–81 . July 1993 . 8377843. 20132912 .
  3. 11015298. 1572337. 2000. Ezeamuzie. C. I. Histamine H(2) receptors mediate the inhibitory effect of histamine on human eosinophil degranulation. British Journal of Pharmacology. 131. 3. 482–8. Philips. E. 10.1038/sj.bjp.0703556.
  4. 18617631. 2008. Fernandez. N. Histamine H2 receptor trafficking: Role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization. Molecular Pharmacology. 74. 4. 1109–18. Monczor. F. Baldi. A. Davio. C. Shayo. C. 10.1124/mol.108.045336. 21485434 . 11336/25894. free.
  5. 18761715. 2008. Threlfell. S. Constitutive histamine H2 receptor activity regulates serotonin release in the substantia nigra. Journal of Neurochemistry. 107. 3. 745–55. Exley. R. Cragg. S. J. Greenfield. S. A. 10.1111/j.1471-4159.2008.05646.x. free.

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