Amphenicol Explained

Amphenicols are a class of antibiotics with a phenylpropanoid structure. They function by blocking the enzyme peptidyl transferase on the 50S ribosome subunit of bacteria.[1]

Examples of amphenicols include chloramphenicol, thiamphenicol, azidamfenicol, and florfenicol. The first-in-class compound was chloramphenicol, introduced in 1949. Chloramphenicol was initially discovered as a natural product and isolated from the soil bacteria Steptomyces venezuelae;[2] however, all amphenicols are now made by chemical synthesis.[3]

References

  1. Web site: APVMA: Florfenicol . 2007-07-22 . https://web.archive.org/web/20070907152939/http://www.apvma.gov.au/archive/gazette0307p13.shtml . 2007-09-07 . dead .
  2. Book: 10.1016/B978-008055232-3.61439-4 . Chloramphenicol . X Pharm: The Comprehensive Pharmacology Reference . 2007 . Scholar . Eric . 1–7 . 9780080552323 .
  3. 10.1007/s00216-010-3724-6 . Evidence of natural occurrence of the banned antibiotic chloramphenicol in herbs and grass . 2010 . Berendsen . Bjorn . Stolker . Linda . De Jong . Jacob . Nielen . Michel . Tserendorj . Enkhtuya . Sodnomdarjaa . Ruuragchas . Cannavan . Andrew . Elliott . Christopher . Analytical and Bioanalytical Chemistry . 397 . 5 . 1955–1963 . 20431869 . 2886120 .

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