Amoscanate Explained

Amoscanate (INN), also known as nithiocyamine, is an experimental anthelmintic agent of the aryl isothiocyanate class which was found to be highly effective in animals against the four major species of schistosomes which infect humans,^[1] and is also highly active against hookworm infection.^{[2] [3]} However, significant liver toxicity was seen in lab animals at higher doses. The ether analogue of amoscanate, nitroscanate, is used in veterinary medicine as an anthelmintic.

Amoscanate was developed by Ciba.^{[4] [5]}

Notes and References

1. Shapiro TA, Were JB, Talalay P . Clinical evaluation of amoscanate in healthy male volunteers . Am. J. Trop. Med. Hyg. . 35 . 5 . 945–53 . September 1986 . 10.4269/ajtmh.1986.35.945 . 3766854 . etal.
2. Doshi JC, Vaidya AB, Sen HG, Mankodi NA, Nair CN, Grewal RS . Clinical trials of a new anthelmintic, 4-isothiocyanato-4'-nitrodiphenylamine (C.9333-Go/CGP 4540), for the cure of hookworm infection . Am. J. Trop. Med. Hyg. . 26 . 4 . 636–9 . July 1977 . 10.4269/ajtmh.1977.26.636 . 889004 .
3. Singh DS, Bala-Subramaniam R, Bhatia VN, Kumar V, Chandrasekar S . Study of the efficacy of compound Go.9333 (Ciba-Geigy) in hookworm infestation . Chemotherapy . 27 . 3 . 220–3 . 1981 . 7014129 . 10.1159/000237981.
4. Vaidya AB, Sen HG, Mankodi NA, Paul T, Sheth UK . Phase 1 tolerability and searching dose studies with 4-isothiocyanato-4'-nitrodiphenylamine (C.9333-Go/CGP 4540), a new anthelmintic . Br J Clin Pharmacol . 4 . 4 . 463–7 . August 1977 . 901739 . 1429051 . 10.1111/j.1365-2125.1977.tb00763.x.
5. Book: Sharma S . Helminth diseases . Progress in Drug Research . 31 . Jucker E . Birkhauser . Boston . 1987 . 3-7643-1837-6 . https://books.google.com/books?id=gx6dwxmlQwMC&dq=amoscanate&pg=PA23 . Retrieved on September 10, 2008 through Google Book Search.