Amixetrine Explained

Amixetrine (INN) (brand name Somagest; developmental code name CERM-898) is a drug that was formerly marketed in France but is now no longer sold.[1] [2] According to various sources it has been said to be an anti-inflammatory, antidepressant, antispasmodic, anticholinergic, antihistamine, and antiserotonergic, but its definitive indications and pharmacology are unclear. The drug was first synthesized in 1969 and was introduced in France in 1972.

Synthesis

The treatment of isoamyl alcohol (1) with styrene (2) at -10°C with dropwise addition of tert-Butyl Hypobromite [1611-82-1] gives (2-bromo-1-(isopentyloxy)ethyl)benzene [5452-50-6] (3). Displacement of the halogen leaving group by pyrrolidine completes the synthesis of amixetrine (4).

Notes and References

  1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 80–.
  2. Book: William Andrew Publishing. Amixetrine Hydrochloride . Pharmaceutical Manufacturing Encyclopedia . 3rd. https://books.google.com/books?id=_J2ti4EkYpkC&pg=PA285. 22 October 2013. Elsevier. 978-0-8155-1856-3. 285–.