Aminopeptidase A inhibitor explained

Aminopeptidase A inhibitors are a class of antihypertensive drugs that work by inhibiting the conversion of angiotensin II to angiotensin III by the aminopeptidase A enzyme. The first medication in this class is firibastat.[1] [2] [3] It is hypothesized that the drugs may be more effective in overweight people and those of African descent.[4]

Notes and References

  1. Blazek . Olivia . Bakris . George L . Novel Therapies on the Horizon of Hypertension Management . American Journal of Hypertension . 13 February 2023 . 36 . 2 . 73–81 . 10.1093/ajh/hpac111 . free . 36201204 .
  2. Ojha . Utkarsh . Ruddaraju . Sanjay . Sabapathy . Navukkarasu . Ravindran . Varun . Worapongsatitaya . Pitchaya . Haq . Jeesanul . Mohammed . Raihan . Patel . Vinod . Current and Emerging Classes of Pharmacological Agents for the Management of Hypertension . American Journal of Cardiovascular Drugs . 2022 . 22 . 3 . 271–285 . 10.1007/s40256-021-00510-9 . 1175-3277. free . 34878631 . 8651502 .
  3. Khosla . Jagjit . Aronow . Wilbert S. . Frishman . William H. . Firibastat: An Oral First-in-Class Brain Aminopeptidase A Inhibitor for Systemic Hypertension . Cardiology in Review . January 2022 . 30 . 1 . 50–55 . 10.1097/CRD.0000000000000360. 33027067 .
  4. Lazartigues . Eric . Llorens-Cortes . Catherine . Danser . A. H. Jan . New Approaches Targeting the Renin-Angiotensin System: Inhibition of Brain Aminopeptidase A, ACE2 Ubiquitination, and Angiotensinogen . Canadian Journal of Cardiology . 2023 . 1900–1912 . 39 . 12 . 10.1016/j.cjca.2023.06.013 . English . 0828-282X. free . 37348757 .

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