Amikhelline Explained

Amikhelline is an antimitotic drug.[1] It acts as a DNA intercalator[2] and inhibits DNA polymerase.[3]

Notes and References

  1. Turchini MF, Geneix A, Perissel B, Malet P, Turchini JP . [Characterization of chromosomal aberrations induced in man by various antimitotic agents] . Comptes Rendus des Séances de la Société de Biologie et de ses Filiales . 179 . 3 . 331–9 . 2417673 . 1985 .
  2. Rucheton M, Jeanteur P . Studies on amikhellin. I. Intercalative binding to double-stranded DNA . Biochimie . 55 . 11 . 1415–20 . 4364376 . 10.1016/s0300-9084(74)80548-1 . 1973 .
  3. Rucheton M, Jeanteur P . Studies on amikhellin. II.-Inhibition of dna-polymerase from murine sarcoma leukemia virus . Biochimie . 58 . 6 . 689–95 . 60141 . 10.1016/s0300-9084(76)80393-8 . 1976 .

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