Amidrine Explained

Amidrine, Midrin, Nodolor, Duradrin, IDA, Migquin, Migrin-A, Migrazone or Epidrine is a combination drug consisting of paracetamol, dichloralphenazone and isometheptene used to treat migraines and severe, refractory headaches.[1]

Components

Availability

Midrin was discontinued by Caraco Pharmaceuticals as of 2009, after an FDA seizure of 33 drugs manufactured by Caraco Pharmaceuticals due to cGMP (Current Good Manufacturing Practices) violations.[2] Generic forms of Amidrine were also discontinued due to loss of FDA grandfather approval status. Thus, manufacturer interest faded. The discontinued generic forms are: Amidrine (Actavis), Duradrin (Barr), I.D.A (Teva), Migquin (Qualitest), Migrin-A (Prasco) and Migrazone (Breckenridge).[3] However, it is now being manufactured by Macoven Pharmaceuticals and marketed under the name Nodolor, as of April 2014. It can also be obtained through a compounding pharmacy with a doctor's prescription.

Notes and References

  1. Freitag. Frederick G.. Cady. Roger. DiSerio. Frank. 20 Dec 2001. Comparative Study of a Combination of Isometheptene Mucate, Dichloralphenazone With Acetaminophen and Sumatriptan Succinate in the Treatment of Migraine. Headache. 41. 4. 391–8. 10.1046/j.1526-4610.2001.111006391.x. 11318886 . 35970757 .
  2. Web site: Questions and Answers: Seizure of Drug Products Manufactured by Caraco Pharmaceutical Laboratories Ltd.. .
  3. Web site: Drug Profiles: MIDRIN®.