Amfecloral (INN), also known as amphecloral (USAN), is a stimulant drug of the phenethylamine and amphetamine chemical classes that was used as an appetite suppressant under the trade name Acutran, but is now no longer marketed.[1] It was classified as an anorectic drug with little to no stimulant activity in a 1970 review.[2] The British Pharmacopoeia Commission approved the name in 1970.[3] The raw ingredients used in manufacturing it were d-amphetamine and chloral hydrate.[4]
Amfecloral is metabolised to both d-(S)- and l-(R)-amphetamine and, most likely, also to chloral hydrate.[5] Amphetamine is a psychostimulant, whereas chloral hydrate is a sedative/hypnotic drug.
The extent of metabolism and in-vivo contribution of a chloral hydrate metabolism to its purported "little to no stimulant activity" is unknown.