Ameltolide Explained

Ameltolide, a 4-aminobenzamide derivative, is an experimental anticonvulsant agent, effective at inhibiting seizures in animal models.[1] It is non-toxic at dosing levels and no undesirable side effects are attributable to its application.[2]

Notes and References

  1. Robertson DW, Beedle EE, Krushinski JH, Lawson RR, Parli CJ, Potts B, Leander JD . Synthesis and pharmacological evaluation of a major metabolite of ameltolide, a potent anticonvulsant . Journal of Medicinal Chemistry . 34 . 4 . 1253–7 . April 1991 . 2016702 . 10.1021/jm00108a003 .
  2. Higdon GL, McKinley ER, Markham JK . Ameltolide. I: Developmental toxicology studies of a novel anticonvulsant . Teratology . 44 . 1 . 37–44 . July 1991 . 1957261 . 10.1002/tera.1420440107 .

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