| Honorific-Prefix: | Archbishop |
| Ambrose Rayappan | |
| Archbishop Emeritus of Pondicherry and Cuddalore | |
| See: | Pondicherry and Cuddalore |
| Appointed: | 7 August 1953 |
| Term Start: | 25 March 1953 |
| Term End: | 17 March 1973 |
| Predecessor: | Auguste-Siméon Colas |
| Successor: | Venmani S. Selvanather |
| Ordination: | 16 December 1923 |
| Consecration: | 25 March 1953 |
| Consecrated By: | Auguste-Siméon Colas |
| Birth Name: | Ambrose Rayappan |
| Birth Date: | 1901 2, df=yes |
| Birth Place: | Dharapuram |
| Death Place: | Pondicherry |
| Buried: | Cathedral Cemetery, Pondicherry |
| Religion: | Catholic |
| Motto: | Fides Vincit Mundum |
| Coat Of Arms: | CoA Ambrose Rayappan.svg |
Ambrose Rayappan (25 February 1901 – 24 November 1999) was the tenth and the first indigenous Archbishop of the Archdiocese of Pondicherry and Cuddalore.[1] He was born at Dharapuram, Tamil Nadu. He was ordained as a priest for the Diocese of Coimbatore on 16 December 1923. He participated in the Second Vatican council as a Council Father.
On 8 January 1953 he was appointed auxiliary bishop of Pondicherry and Cuddalore, and was consecrated on 25 March 1953 by Auguste-Siméon Colas. He was appointed as coadjutor of the same archdiocese on 7 August 1953. When Mgr. Colas resigned, he succeeded him on 28 November 1955. He resigned his post on 17 March 1973. He was succeeded by Venmani S. Selvanather.
| Dipstyle: | The Most Reverend |
| Offstyle: | Your Excellency |
| Relstyle: | Monsignor |