| Amadou Karim Gaye | |
| Termend2: | 1979 |
| Nationality: | Senegalese |
| Death Place: | Dakar |
| Birth Place: | Saint-Louis, Senegal |
| Birth Date: | 3 November 1913 |
| Termstart2: | 1975 |
| Office: | Foreign Minister of Senegal |
| Successor2: | Habib Chatti |
| Predecessor2: | Hassan Touhami |
| Office2: | Secretary General of the Organization of the Islamic Conference |
| Successor: | Coumba Ndoffène Diouf |
| Predecessor: | Alioune Badara Mbengue |
| Termend: | 1972 |
| Termstart: | 1968 |
Amadou Karim Gaye (November 8, 1913 – October 2, 2000) was a Senegalese veterinarian, physician and politician from Saint-Louis. He served as Foreign Minister of Senegal from 1968–1972.