Amabiline Explained

Amabiline is a pyrrolizidine alkaloid first isolated in 1967 from Cynoglossum amabile.[1] It is also found in the seeds and flowers of borage (Borago officinalis)[2] and in borage seed oil.[3] [4]

Chemically, it is the ester derived from viridifloric acid and supinidine.[5]

Amabiline is hepatotoxic and may contribute to the potential liver damage caused by consumption of borage and its seed oil.[6]

Notes and References

  1. 10.1071/CH9672499 . The alkaloids of Cynoglossum australe R.Br. And C. Amabile Stapf & Drummond . Australian Journal of Chemistry . 20 . 11 . 2499 . 1967 . Culvenor . CCJ . Smith . LW .
  2. 10.1021/np50046a045 . Pyrrolizidine Alkaloids from Borage (Borago officinalis) Seeds and Flowers . Journal of Natural Products . 49 . 4 . 727–728 . 1986 . Dodson . Craig D. . Stermitz . Frank R. .
  3. TLC detection of pyrrolizidine alkaloids in oil extracted from the seeds of Borago officinalis . Parvais, O. . Vander Stricht, B. . Vanhaelen-Fastre, R. . Vanhaelen, M. . Journal of Planar Chromatography--Modern TLC . 1994 . 7 . 1 . 80–82.
  4. Wretensjoe, Inger . Karlberg, Bo. . Pyrrolizidine alkaloid content in crude and processed borage oil from different processing stages . Journal of the American Oil Chemists' Society . 2003 . 80 . 10 . 963–970 . 10.1007/s11746-003-0804-z. 94575246 .
  5. Book: The Alkaloids: Chemistry and Physiology . Academic Press . 1970 . 302–303 .
  6. Web site: Borage . 31 March 2022 . .

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