| Américo Ruffino | |
| Birth Date: | 27 July 1905 |
| Years2: | 192?–1928 |
| Caps2: | ? |
| Goals2: | ? |
| Years3: | 1928–1929 |
| Caps3: | 6 |
| Goals3: | 1 |
| Years4: | 1929–1934 |
| Caps4: | 135 |
| Goals4: | 32 |
| Years5: | 1934–1935 |
| Caps5: | ? |
| Goals5: | ? |
| Years6: | 1935–1936 |
| Caps6: | ? |
| Goals6: | ? |
Américo Ruffino (27 July 1905 – 4 July 1988) was an Argentine football player. Ruffino spent the vast majority of his career with the Palermo team.
A winger, he scored the first Serie A goal in the history of the Sicilian team (1932–33 season, Lazio-Palermo 1-1).