Altropane Explained

Altropane (O-587, IACFT, 2β-carbomethoxy-3β-(4-fluorophenyl)-N-((E)-3-iodo-prop-2-enyl)tropane) is a phenyltropane derivative which acts as a potent dopamine reuptake inhibitor and long-acting stimulant drug. It has mainly been used as the ¹²⁵I radiolabelled form for mapping the distribution of dopamine transporters in the brain,^[1] and consequently this has led to its development as a potential diagnostic tool for early detection of Parkinson's disease.^[2] It is also being investigated for potential use in the diagnosis and treatment of attention deficit hyperactivity disorder (ADHD).^{[3] [4]}

Notes and References

1. Elmaleh DR, Fischman AJ, Shoup TM, Byon C, Hanson RN, Liang AY, Meltzer PC, Madras BK . 6 . Preparation and biological evaluation of iodine-125-IACFT: a selective SPECT agent for imaging dopamine transporter sites . Journal of Nuclear Medicine . 37 . 7 . 1197–202 . July 1996 . 8965198 .
2. Fischman AJ, Bonab AA, Babich JW, Palmer EP, Alpert NM, Elmaleh DR, Callahan RJ, Barrow SA, Graham W, Meltzer PC, Hanson RN, Madras BK . 6 . Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters . Synapse . 29 . 2 . 128–41 . June 1998 . 9593103 . 10.1002/(SICI)1098-2396(199806)29:2<128::AID-SYN4>3.0.CO;2-9 . 30543189 .
3. Cattabeni F . Altropane (Boston Life Science) . Current Opinion in Investigational Drugs . 3 . 11 . 1647–51 . November 2002 . 12476968 .
4. Spencer TJ, Biederman J, Madras BK, Dougherty DD, Bonab AA, Livni E, Meltzer PC, Martin J, Rauch S, Fischman AJ . 6 . Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using altropane . Biological Psychiatry . 62 . 9 . 1059–61 . November 2007 . 17511972 . 10.1016/j.biopsych.2006.12.008 . 2715944 .