| Competition: | Alpha Ethniki |
| Season: | 1959–60 |
| Winners: | Panathinaikos 4th Greek title |
| Relegated: | Pankorinthiakos Megas Alexandros Katerinis AE Nikaia |
| Continentalcup1 Qualifiers: | Panathinaikos |
| League Topscorer: | Kostas Nestoridis (33 goals) |
| Highest Scoring: | |
| Matches: | 240 |
| Total Goals: | 619 |
| Prevseason: | 1958–59 (Panhellenic Championship) |
| Nextseason: | 1960–61 |
The 1959–60 Alpha Ethniki was the 24th season of the highest football league of Greece and the first season of the nationwide league after the league replaced the Panhellenic Championship. The season began on 25 October 1959 and ended on 31 July 1960 with the play-off matches. Panathinaikos won their fourth Greek title and their first in seven years.
The 16 teams that formed the first national championship were resulted as follows:
The point system was: Win: 3 points - Draw: 2 points - Loss: 1 point.
Initially there were going to be 18 teams in the first division, however, the delay of 6 weeks in the start of the event due to the financial negotiations between the involved parties General Secretary of Sport, OPAP, HFF and in some places FCAs, put its serious completion in a timely manner. The HFF took the decision to reduce the number of teams to 16 and as a consequence a promotional play-off round was formed to decide the last two places of the championship.
|}
Olympiacos Chalkida qualifies to the promotional Play-offs.
|+South|}|+North|}
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | Kostas Nestoridis | AEK Athens | 33 |
| 2 | Giorgos Kamaras | Apollon Athens | 19 |
| 3 | Elias Yfantis | Olympiacos | 16 |
| 4 | Pavlos Grigoriadis | Doxa Drama | 14 |
| 5 | Giannis Cholevas | Apollon Athens | 13 |
| 6 | Vangelis Karafoulidis | Megas Alexandros Katerinis | 11 |
| Lakis Sofianos | Panegialios | ||
| Andreas Stamatiadis | AEK Athens |