Alpha/beta hydrolase superfamily explained

Symbol:	Abhydrolase_1
Width:	250
Pfam:	PF00561
Pfam Clan:	CL0028
Ecod:	7579.1.1
Interpro:	IPR029058
Scop:	1ede
Opm Family:	127
Opm Protein:	1qge
Cdd:	cl21494
Membranome Superfamily:	300

The alpha/beta hydrolase superfamily is a superfamily of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function that share a common fold.^[1] The core of each enzyme is an alpha/beta-sheet (rather than a barrel), containing 8 beta strands connected by 6 alpha helices.^[2] The enzymes are believed to have diverged from a common ancestor, retaining little obvious sequence similarity, but preserving the arrangement of the catalytic residues. All have a catalytic triad, the elements of which are borne on loops, which are the best-conserved structural features of the fold.

The alpha/beta hydrolase fold includes proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases.^[3]

Database

The ESTHER database provides a large collection of information about this superfamily of proteins.^[4]

Human proteins containing this domain

ABHD10

ABHD11; ABHD12; ABHD12B; ABHD13; ABHD2; ABHD3; ABHD4;ABHD5

ABHD6; ABHD7; ABHD8; ABHD9; BAT5; BPHL; C20orf135;EPHX1

EPHX2; FAM108B1; LIPA; LIPF; LIPJ; LIPK; LIPM;LIPN

LYPLAL1; MEST; MGLL; PPME1; SERHL; SERHL2; SPG21; CES1; CES2; C4orf29

See also

• Ecdysteroid-phosphate phosphatase - structure of a steroid phosphate phosphotase
• Serine hydrolase - an enzyme family that is composed largely of proteins with alpha-beta hydrolase folds

External links

• The ESTHER database

References

1. Ollis, D. L. . Cheah, E. . Cygler, M. . Dijkstra, B. . Frolow, F. . Franken, S. M. . Harel, M. . Remington, S. J. . Silman, I. . Schrag, J. . Sussman, J. L. . Verschueren, K. H. G. . Goldman, A. . amp . The alpha/beta hydrolase fold . Protein Eng. . 5 . 3 . 197–211 . 1992 . 1409539 . 10.1093/protein/5.3.197. 11370/2d4c057d-1a67-437d-ad10-701f7a60f1e6 . free .
2. Carr PD, Ollis DL . Alpha/beta hydrolase fold: an update . Protein Pept. Lett. . 16 . 10 . 1137–48 . 2009 . 19508187 . 10.2174/092986609789071298.
3. Nardini M, Dijkstra BW . Alpha/beta hydrolase fold enzymes: the family keeps growing . Curr. Opin. Struct. Biol. . 9 . 6 . 732–7 . December 1999 . 10607665 . 10.1016/S0959-440X(99)00037-8.
4. Renault L, Nègre V, Hotelier T, Cousin X, Marchot P, Chatonnet A . New friendly tools for users of ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins . Chem. Biol. Interact. . 157-158 . 339–43 . December 2005 . 16297901 . 10.1016/j.cbi.2005.10.100 .