Alpha-glucuronidase explained

alpha-glucuronidase
Ec Number:	3.2.1.139
Cas Number:	37259-81-7
Go Code:	0046559

For beta-glucuronidase, see Beta-glucuronidase

In enzymology, an alpha-glucuronidase is an enzyme that catalyzes the chemical reaction

an alpha-D-glucuronoside + H₂O

\rightleftharpoons an alcohol + D-glucuronate

Thus, the two substrates of this enzyme are alpha-D-glucuronoside and H₂O, whereas its two products are alcohol and D-glucuronate.

This enzyme belongs to the family of hydrolases, to be specific those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is alpha-D-glucosiduronate glucuronohydrolase. This enzyme is also called alpha-glucosiduronase.

Structural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,,, and .

See also

• Beta-glucuronidase
• Glucuronosyl-disulfoglucosamine glucuronidase
• Glycyrrhizinate beta-glucuronidase

References

• Visser, J., Kusters van Someren, M.A., Beldman, G. and Voragen, A.G.J. (Eds.), Xylans and Xylanases, Elsevier, Amsterdam, 1992, p. 213-224.
• Uchida H, Nanri T, Kawabata Y, Kusakabe I, Murakami K . 1992 . Purification and characterization of intracellular alpha-glucuronidase from Aspergillus niger . Biosci. Biotechnol. Biochem. . 56 . 1608 - 1615 . 10.1271/bbb.56.1608 . 10 .