Alpha-5 beta-1 explained
α5β1, also known as the fibronectin receptor,[1] is an integrin that binds to matrix macromolecules and proteinases and thereby stimulates angiogenesis.[2] It is composed of α5 (ITGA5/CD49e) and β1 (ITGB1/CD29) subunits. It is the primary receptor for fibronectin. The interaction of VLA-5 with fibronectin plays an important role in regulating inflammatory cytokine production by human articular chondrocytes (From the Cell Migration Gateway ITGA5 ITGB1).
α5β1-integrin is transported inside the cell by the kinesin KIF1C,[3] a kinesin-3 organelle transporter that walks along microtubules.
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Notes and References
- Schaffner . F. . Ray . A. . Dontenwill . M. . 2013 . Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors . Cancers . 5 . 4. 27–47 . 10.3390/cancers5010027 . 3730317 . free .
- Boudreau NJ, Varner JA . The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis . J. Biol. Chem. . 279 . 6 . 4862–8 . February 2004 . 14610084 . 10.1074/jbc.M305190200 . free .
- Theisen. U. Straube, E. Straube, A. Directional persistence of migrating cells requires Kif1C-mediated stabilization of trailing adhesions.. Developmental Cell. Dec 11, 2012. 23. 6. 1153–66. 23237952. 10.1016/j.devcel.2012.11.005. free.