Alnespirone Explained

Alnespirone (S-20,499) is a selective 5-HT_1A receptor full agonist of the azapirone chemical class.^{[1] [2] [3]} It has antidepressant and anxiolytic effects.

See also

• 8-OH-DPAT
• Azapirone

Notes and References

1. 10.1097/00001756-199201000-00022 . Griebel G, Misslin R, Pawlowski M, Guardiola Lemaître B, Guillaumet G, Bizot-Espiard J . Anxiolytic-like effects of a selective 5-HT1A agonist, S20244, and its enantiomers in mice. . NeuroReport . 3 . 1 . 84–86 . 1992 . 1351756 .
2. 10.1007/BF02245284 . Simon P, Guardiola B, Bizot-Espiard J, Schiavi P, Costentin J . 5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists. . Psychopharmacology . 108 . 1–2 . 47–50 . 1992 . 1357709 . 22385029 .
3. 10.1016/S0014-2999(02)02814-5 . Astier B, Lambás Señas L, Soulière F, Schmitt P, Urbain N, Rentero N, Bert L, Denoroy L, Renaud B, Lesourd M, Muñoz C, Chouvet G . In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity. . Eur J Pharmacol . 459 . 1 . 17–26 . 2003 . 12505530 .