All-trans-8'-apo-beta-carotenal 15,15'-oxygenase explained

All-trans-8'-apo-beta-carotenal 15,15'-oxygenase
Ec Number:1.14.99.41

All-trans-8'-apo-beta-carotenal 15,15'-oxygenase (Diox1, ACO, 8'-apo-beta-carotenal 15,15'-oxygenase) is an enzyme with systematic name all-trans-8'-apo-beta-carotenal:oxygen 15,15'-oxidoreductase (bond-cleaving).[1] [2] This enzyme catalyses the following chemical reaction

all-trans-8'-apo-beta-carotenal + O2

\rightleftharpoons

all-trans-retinal + (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial

All-trans-8'-apo-beta-carotenal 15,15'-oxygenase contains an Fe2+-4His arrangement.

Notes and References

  1. Ruch S, Beyer P, Ernst H, Al-Babili S . Retinal biosynthesis in Eubacteria: in vitro characterization of a novel carotenoid oxygenase from Synechocystis sp. PCC 6803 . Molecular Microbiology . 55 . 4 . 1015–24 . February 2005 . 15686550 . 10.1111/j.1365-2958.2004.04460.x .
  2. Kloer DP, Ruch S, Al-Babili S, Beyer P, Schulz GE . The structure of a retinal-forming carotenoid oxygenase . Science . 308 . 5719 . 267–9 . April 2005 . 15821095 . 10.1126/science.1108965 .

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