Alkb homolog 1, histone h2a dioxygenase explained

AlkB homolog 1, histone H2A dioxygenase is a protein that in humans is encoded by the ALKBH1 gene.^[1]

Function

This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. [provided by RefSeq, Jul 2008].

See also

• MGMT

Further reading

• Aas PA, Otterlei M, Falnes PO, Vågbø CB, Skorpen F, Akbari M, Sundheim O, Bjørås M, Slupphaug G, Seeberg E, Krokan HE . Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA . Nature . 421 . 6925 . 859–63 . February 2003 . 12594517 . 10.1038/nature01363 . 2003Natur.421..859A . 4352520 .
• Westbye MP, Feyzi E, Aas PA, Vågbø CB, Talstad VA, Kavli B, Hagen L, Sundheim O, Akbari M, Liabakk NB, Slupphaug G, Otterlei M, Krokan HE . Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA . J. Biol. Chem. . 283 . 36 . 25046–56 . September 2008 . 18603530 . 3259822 . 10.1074/jbc.M803776200 . free .
• Müller TA, Meek K, Hausinger RP . Human AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sites . DNA Repair (Amst.) . 9 . 1 . 58–65 . January 2010 . 19959401 . 2818486 . 10.1016/j.dnarep.2009.10.011 .
• Shankaracharya, Das S, Vidyarthi AS . Homology modeling and function prediction of hABH1, involving in repair of alkylation damaged DNA . Interdiscip Sci . 3 . 3 . 175–81 . September 2011 . 21956739 . 10.1007/s12539-011-0087-4 . 187339 .
• Müller TA, Andrzejak MM, Hausinger RP . A covalent protein-DNA 5'-product adduct is generated following AP lyase activity of human ALKBH1 (AlkB homologue 1) . Biochem. J. . 452 . 3 . 509–18 . June 2013 . 23577621 . 4126167 . 10.1042/BJ20121908 .
• Müller TA, Yu K, Hausinger RP, Meek K . ALKBH1 is dispensable for abasic site cleavage during base excision repair and class switch recombination . PLOS ONE . 8 . 6 . e67403 . 2013 . 23825659 . 3692455 . 10.1371/journal.pone.0067403 . 2013PLoSO...867403M . free .
• Fedeles BI, Singh V, Delaney JC, Li D, Essigmann JM . The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond . J. Biol. Chem. . 290 . 34 . 20734–42 . August 2015 . 26152727 . 4543635 . 10.1074/jbc.R115.656462 . free .
• Haag S, Sloan KE, Ranjan N, Warda AS, Kretschmer J, Blessing C, Hübner B, Seikowski J, Dennerlein S, Rehling P, Rodnina MV, Höbartner C, Bohnsack MT . NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation . EMBO J. . 35 . 19 . 2104–2119 . October 2016 . 27497299 . 5048346 . 10.15252/embj.201694885 .
• Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T, He C . ALKBH1-Mediated tRNA Demethylation Regulates Translation . Cell . 167 . 3 . 816–828.e16 . October 2016 . 27745969 . 5119773 . 10.1016/j.cell.2016.09.038 .

Notes and References

1. Web site: Entrez Gene: AlkB homolog 1, histone H2A dioxygenase. 2018-07-12.