AlkB homolog 5, RNA demethylase explained

RNA demethylase ALKBH5 is a protein that in humans is encoded by the ALKBH5 gene.^[1]

Further reading

• Thalhammer A, Bencokova Z, Poole R, Loenarz C, Adam J, O'Flaherty L, Schödel J, Mole D, Giaslakiotis K, Schofield CJ, Hammond EM, Ratcliffe PJ, Pollard PJ . Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α) . PLOS ONE . 6 . 1 . e16210 . 2011 . 21264265 . 3021549 . 10.1371/journal.pone.0016210 . 2011PLoSO...616210T . free .
• Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vågbø CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG, He C . ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility . Mol. Cell . 49 . 1 . 18–29 . 2013 . 23177736 . 3646334 . 10.1016/j.molcel.2012.10.015 .
• Aik W, Scotti JS, Choi H, Gong L, Demetriades M, Schofield CJ, McDonough MA . Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation . Nucleic Acids Res. . 42 . 7 . 4741–54 . 2014 . 24489119 . 3985658 . 10.1093/nar/gku085 .
• Feng C, Liu Y, Wang G, Deng Z, Zhang Q, Wu W, Tong Y, Cheng C, Chen Z . Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition . J. Biol. Chem. . 289 . 17 . 11571–83 . 2014 . 24616105 . 4002068 . 10.1074/jbc.M113.546168 . free .
• Xu C, Liu K, Tempel W, Demetriades M, Aik W, Schofield CJ, Min J . Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation . J. Biol. Chem. . 289 . 25 . 17299–311 . 2014 . 24778178 . 4067165 . 10.1074/jbc.M114.550350 . free .
• Du T, Rao S, Wu L, Ye N, Liu Z, Hu H, Xiu J, Shen Y, Xu Q . An association study of the m6A genes with major depressive disorder in Chinese Han population . J Affect Disord . 183 . 279–86 . 2015 . 26047305 . 10.1016/j.jad.2015.05.025 .
• Zhang C, Samanta D, Lu H, Bullen JW, Zhang H, Chen I, He X, Semenza GL . Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA . Proc. Natl. Acad. Sci. U.S.A. . 113 . 14 . E2047–56 . 2016 . 27001847 . 4833258 . 10.1073/pnas.1602883113 . 2016PNAS..113E2047Z . free .

Notes and References

1. Web site: Entrez Gene: AlkB homolog 5, RNA demethylase. 2017-07-27.