Alinidine Explained

Alinidine (ST567) is a negative chronotrope that was developed in the 1970s and 1980s. It causes bradycardia by inhibiting the pacemaker current by altering the maximal channel conductance and alter the voltage threshold.^[1] The development of alinidine was halted because it was not sufficiently specific for its target. It also has a blocking effect on calcium channels and potassium channels. It also causes elongation of re-polarisation after an action potential.^[2]

Alinidine did not improve outcomes among patients with acute myocardial infarction in a randomized controlled trial.^[3]

Notes and References

1. Snyders DJ, Van Bogaert P-P: Alinidine modifies the pacemaker current in sheep Purkinje fibers. Pflügers Arch 1987, 410:83-91
2. Current Opinion in Pharmacology 2007, 7:208–213
3. Van de Werf F, Janssens L, Brzostek T, Mortelmans L, Wackers FJ, Willems GM . Short-term effects of early intravenous treatment with a beta-adrenergic blocking agent or a specific bradycardiac agent in patients with acute myocardial infarction receiving thrombolytic therapy. . J Am Coll Cardiol . 1993 . 22 . 2 . 407–16 . 8335810 . 10.1016/0735-1097(93)90044-2. etal. free .