Alice Vrielink Explained

Alice Vrielink
Alma Mater:University of London
Thesis Title:The crystal structure determination of cholesterol oxidase
Thesis Url:https://www.worldcat.org/oclc/
Thesis Year:1989
Doctoral Advisor:David Mervyn Blow[1]

Alice Vrielink is a structural biologist and Professor of Structural Biology in the School of Molecular Sciences at the University of Western Australia. She is known for her work determining the structures of macromolecules such as enzymes and nucleic acids.

Education

Vrielink earned a Bachelor of Science in Chemistry and Masters of Science in Physical Chemistry at the University of Calgary in Canada.[2] For her master's research she worked on ligands of angiotensin, a hormone involved in regulating blood pressure.[3] She received a PhD in 1989 from the University of London where she worked on the structure of cholesterol oxidase.[4] She also has a Diploma in Crystallography from the Imperial College of Science and Technology.

Career

Vrielink was an Assistant and Associate Professor at McGill University in Canada from 1994 to 2001.[2] From 2000 until 2007 she served as a Research Professor at the University of California, Santa Cruz and then joined the faculty at University of Western Australia as Professor of Structural Biology in 2007.[2]

Vrielink was a member of the 2014 National Committee on Crystallography[5] She is a past president of the Society of Crystallographers of Australia and New Zealand (SCANZ).[6]

Research

Vrielink conducts research in protein biochemistry and crystallography with a special focus on understanding the structural determinants governing enzyme chemistry.[7] Vrielink's early research centered on the three-dimensional structure of the enzyme cholesterol oxidase first in Brevibacterium[8] [9] and then in Streptomyces.[10]

She has been involved in projects that have established the structure of compounds including L-amino-acid oxidase,[11] prions,[12] and snake venom.[13] In 2017, she mapped the molecular structure of EptA,[14] a protein that shields superbugs from antibiotics. This work has been covered by the BBC,[15] ABC,[16] Times Higher Education,[17] The West Australian,[18] and Particle.[19] Subsequent work on EptA has revealed why it may be a good target for drug development.[20] [21]

Selected publications

External links

Notes and References

  1. Web site: Vrielink. Alice. 2014-07-03. David Blow (1931-2004) - A Remberance. live. 2021-10-14. American Crystallographic Association. https://web.archive.org/web/20140703002900/http://www.amercrystalassn.org/documents/newsletterarchive/2004Winter.pdf. 2014-07-03.
  2. Web site: Researcher Profile: Professor Alice Vrielink. UWA Research Repository.
  3. Structural and conformational energy studies of ligands of angiotensin converting enzyme and thermolysin. National Library of Canada. 1986. Ottawa. English. Alice. Vrielink. 16710356.
  4. Book: Vrielink. Alice. The crystal structure determination of cholesterol oxidase.. University of London. 1989. 10044/1/47699. English. 1063590654.
  5. https://www.science.org.au/academy-newsletter/australian-academy-science-newsletter-98/national-committees "Triennial Congress and General Assembly"
  6. News: From the President. Vrielink. Alice. 2016. Scanz Newsletter. 7 February 2018.
  7. Ducy, Liam. "UWA celebrates Australian link in scientific breakthrough". WAToday, August 20, 2014.
  8. Li. Jiayao. Vrielink. Alice. Brick. Peter. Blow. David M.. 1993-01-26. Crystal structure of cholesterol oxidase complexed with a steroid substrate: Implications for flavin adenine dinucleotide dependent alcohol oxidases. Biochemistry. 32. 43. 11507–11515. 10.1021/bi00094a006. 8218217. 0006-2960.
  9. Vrielink. Alice. Lloyd. Lesley F. Blow. David M. 1991-06-05. Crystal structure of cholesterol oxidase from Brevibacterium sterolicum refined at 1.8 Å resolution. Journal of Molecular Biology. en. 219. 3. 533–554. 10.1016/0022-2836(91)90192-9. 2051487. 0022-2836.
  10. Yue. Q. Kimberley. Kass. Ignatius J.. Sampson. Nicole S.. Vrielink. Alice. 1999-04-01. Crystal Structure Determination of Cholesterol Oxidase from Streptomyces and Structural Characterization of Key Active Site Mutants. Biochemistry. en. 38. 14. 4277–4286. 10.1021/bi982497j. 10194345. 0006-2960.
  11. Pawelek. P. D.. 2000-08-15. The structure of L-amino acid oxidase reveals the substrate trajectory into an enantiomerically conserved active site. The EMBO Journal. 19. 16. 4204–4215. 10.1093/emboj/19.16.4204. 302035. 10944103.
  12. Burns. Colin S.. Aronoff-Spencer. Eliah. Dunham. Christine M.. Lario. Paula. Avdievich. Nikolai I.. Antholine. William E.. Olmstead. Marilyn M.. Vrielink. Alice. Gerfen. Gary J.. Peisach. Jack. Scott. William G.. 2002-03-01. Molecular Features of the Copper Binding Sites in the Octarepeat Domain of the Prion Protein. Biochemistry. 41. 12. 3991–4001. 10.1021/bi011922x. 11900542. 2905306. 0006-2960.
  13. Kang. Tse Siang. Georgieva. Dessislava. Genov. Nikolay. Murakami. Mário T.. Sinha. Mau. Kumar. Ramasamy P.. Kaur. Punit. Kumar. Sanjit. Dey. Sharmistha. Sharma. Sujata. Vrielink. Alice. 2011. Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis. The FEBS Journal. en. 278. 23. 4544–4576. 10.1111/j.1742-4658.2011.08115.x. 21470368. 40199362. 1742-4658. free.
  14. Anandan. Anandhi. Evans. Genevieve L.. Condic-Jurkic. Karmen. O’Mara. Megan L.. John. Constance M.. Phillips. Nancy J.. Jarvis. Gary A.. Wills. Siobhan S.. Stubbs. Keith A.. Moraes. Isabel. Kahler. Charlene M.. Vrielink. Alice. 2017-02-28. Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding. Proceedings of the National Academy of Sciences. en. 114. 9. 2218–2223. 10.1073/pnas.1612927114. 0027-8424. 5338521. 28193899. 2017PNAS..114.2218A . free.
  15. News: Dunlop. Greg. 15 February 2017. Antibiotic resistance: Scientists 'unmask' superbug-shielding protein. BBC News. 7 February 2018.
  16. News: Wildie. Tom. 14 February 2017. Australian scientists make breakthrough in fight against superbugs. ABC News. 7 February 2018.
  17. Web site: Stopping the rise of the superbug. dead. https://web.archive.org/web/20180208004709/http://timeshighereducationonline.com/the-university-of-western-australia/p/stopping-superbugs. 2018-02-08. 2018-02-07. Times Higher Education.
  18. News: O'Leary. Cathy. 14 February 2017. UWA breakthrough in superbug battle. The West Australian. 7 February 2018.
  19. Web site: Mitchell. Samille. 14 March 2017. WA Scientists Fight Deadly Superbugs. Particle.
  20. Kahler. Charlene M.. Nawrocki. K. L.. Anandan. A.. Vrielink. Alice. Shafer. William M.. 2018. Structure-Function Relationships of the Neisserial EptA Enzyme Responsible for Phosphoethanolamine Decoration of Lipid A: Rationale for Drug Targeting. Frontiers in Microbiology. 9. 1922. 10.3389/fmicb.2018.01922. 30186254. 6111236. 1664-302X. free.
  21. Anandan. Anandhi. Dunstan. Nicholas W.. Ryan. Timothy M.. Mertens. Haydyn D. T.. Lim. Katherine Y. L.. Evans. Genevieve L.. Kahler. Charlene M.. Vrielink. Alice. 2021-09-01. Conformational flexibility of EptA driven by an interdomain helix provides insights for enzyme–substrate recognition. IUCrJ. 8. 5. 732–746. 10.1107/S2052252521005613. 2052-2525. 8420757. 34584735.

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