| Ali Shamsuddin | |
| Native Name: | علي شمس الدّين |
| Honorific Suffix: | 22nd Da'i al-Mutlaq of the Dawoodi Bohra |
| Death Date: | 21 Zilqad 933 AH (1527 CE) |
| Resting Place: | Masar, Yemen |
| Office1: | Da'i al-Mutlaq |
| Term Start1: | 10th Shawwal 933 AH (1527 CE) |
| Term End1: | 21st Zilqad 933 AH (1527 CE) |
| Predecessor1: | al-Husayn Husam al-Din |
| Successor1: | Muhammad Izz al-Din I |
| Father: | al-Husayn Husam al-Din |
| Religion: | Islam |
| Sect: | Isma'ili |
| Subsect: | Dawoodi Bohra |
| Background: |
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Ali Shams al-Din ibn al-Husayn Husam al-Din (; died 1527) was the 22nd of Tayyibi Isma'ilis in 1527.
His incumbency was among the shortest of all Da'is, lasting more than a month.[1] He was the successor to the 21st Da'i al-Husayn Husam al-Din to the religious post.