Alev Erisir Explained
Alev Erisir is a Turkish-American neuroscientist.[1] She is a professor of psychology and the department chair at the University of Virginia in Charlottesville. Her primary research areas include synaptic connectivity in the visual and taste systems, neuronal circuit plasticity, and ultrastructural neuroanatomy.[2]
Early life and education
Erisir was born in Kastamonu, Turkey. Her father was stationed in Kastamonu as a malaria eradication doctor. As an infant, Erisir moved with her family to Canakkale, Turkey, where she grew up until the age of 11. The family then moved to Istanbul, Turkey, where Erisir completed her secondary education. In 1986, following high school graduation, Erisir attended Istanbul University School of Medicine and received her MD. In 1996, Erisir graduated from the State University of New York at Stony Brook with a PhD in Behavioral Neuroscience.[3]
Research and career
Erisir completed postdoctoral training at New York University (NYU) Center for Neural Science. She completed her training under the guidance of Chiye Aoki. In Aoki's laboratory, Professor Erisir trained specifically in Electron Microscopy. After completing her training at NYU, Erisir completed a one-year postdoctoral appointment at New York Medical College (NYMC) in the department of Physiology. Following her time at NYMC, Erisir returned to NYU this time as a Research Assistant Professor.[4]
In 2000, Erisir started working at University of Virginia (UVA) as an assistant professor. In 2013, she was granted professor status at UVA. During her time at UVA, Erisir has served in several administrative roles, including co-director of the neuroscience graduate program, director of the cognitive science program, and director of the neuroscience undergraduate program. In 2016, she was appointed to be the chair of the psychology department at UVA.
At UVA, Erisir's research has consisted of investigating ocular dominance column plasticity using several different techniques, brain stem gustatory circuitry, the aging brain and its pathology, and three-dimensional connectomics.
Erisir conducts studies on cellular mechanisms within the aging brain and neurodegenerative diseases such as Alzheimer's disease. Her work examines the relationship between hyperactive oligodendrocytes and cognitive impairments in Alzheimer's mouse models. Additionally, Erisir's research examines proteins such as beta-amyloid and tau that result in the loss of synaptic plasticity.[5]
In 2008, Erisir received a University of Virginia Mead Grant, which funded an opportunity for Erisir to take undergraduates to the annual Society of Neuroscience conference.[6] In 2010, she mentored a research project that investigated rodent neural circuitry between the brainstem and the oral cavity. This project was selected by the University of Virginia to receive the "Double Hoo" Grant.[7]
Selected publications
- Campbell. Charles. Lindhartsen. Sarah. Knyaz. Adam. Erisir. Alev. Nahmani. Marc. October 15, 2020. Cortical Presynaptic Boutons Progressively Engulf Spinules as They Mature. eNeuro. 7. 5. 10.1523/ENEURO.0426-19.2020. 2373-2822. 7568603. 32958478.
- Sanchez. Victoria. Bakhti-Suroosh. Anousheh. Chen. Andrew. Brunzell. Darlene H.. Erisir. Alev. Lynch. Wendy J.. 19 March 2019. Exercise during abstinence normalizes ultrastructural synaptic plasticity associated with nicotine-seeking following extended access self-administration. European Journal of Neuroscience. en. 50. 4. 2707–2721. 10.1111/ejn.14408. 0953-816X. 6742551. 30888721.
- Wang. L. Kloc. M. Maher. E. Erisir. A. Maffei. A. 2019-03-01. Presynaptic GABAA Receptors Modulate Thalamocortical Inputs in Layer 4 of Rat V1. Cerebral Cortex. en. 29. 3. 921–936. 10.1093/cercor/bhx364. 29373653. 1047-3211.
- Schecter. Rachel W.. Maher. Erin E.. Welsh. Christina A.. Stevens. Beth. Erisir. Alev. Bear. Mark F.. 2017-11-01. Experience-Dependent Synaptic Plasticity in V1 Occurs without Microglial CX3CR1. The Journal of Neuroscience . 37. 44. 10541–10553. 10.1523/JNEUROSCI.2679-16.2017. 1529-2401. 5666579. 28951447.
- Irwin. Jacob A.. Erisir. Alev. Kwon. Inchan. 2016. Oral Triphenylmethane Food Dye Analog, Brilliant Blue G, Prevents Neuronal Loss in APPSwDI/NOS2-/- Mouse Model. Current Alzheimer Research. 13. 6. 663–677. 10.2174/15672050136661602081424568 . 31 January 2024 . 1875-5828. 5441128. 26852943.
- Holtz. Stephen L.. Fu. Anqi. Loflin. Wyatt. Corson. James A.. Erisir. Alev. 2015-01-01. Morphology and connectivity of parabrachial and cortical inputs to gustatory thalamus in rats. The Journal of Comparative Neurology. 523. 1. 139–161. 10.1002/cne.23673. 1096-9861. 4232453. 25186035.
- Corson. James A.. Erisir. Alev. 2013-09-01. Monosynaptic convergence of chorda tympani and glossopharyngeal afferents onto ascending relay neurons in the nucleus of the solitary tract: a high-resolution confocal and correlative electron microscopy approach. The Journal of Comparative Neurology. 521. 13. 2907–2926. 10.1002/cne.23357. 1096-9861. 3953562. 23640852.
- Owe. S. G.. Erisir. A.. Heggelund. P.. 2013-07-23. Terminals of the major thalamic input to visual cortex are devoid of synapsin proteins. Neuroscience. 243. 115–125. 10.1016/j.neuroscience.2013.03.031. 1873-7544. 3953556. 23535254.
- Wang. Siting. Corson. James. Hill. David. Erisir. Alev. 2012-10-01. Postnatal development of chorda tympani axons in the rat nucleus of the solitary tract. The Journal of Comparative Neurology. en. 520. 14. 3217–3235. 10.1002/cne.23093. 3418376. 22430892.
- Corson. James. Aldridge. Alexandra. Wilmoth. Kristin. Erisir. Alev. 2012-02-15. A survey of oral cavity afferents to the rat nucleus tractus solitarii. The Journal of Comparative Neurology. en. 520. 3. 495–527. 10.1002/cne.22715. 3371193. 21800298.
- 2009-10-20. Sensory activity differentially modulates N-methyl-d-aspartate receptor subunits 2A and 2B in cortical layers. Neuroscience. en. 163. 3. 920–932. 10.1016/j.neuroscience.2009.07.016. 0306-4522. 2746878. 19596055. Corson . J. . Nahmani . M. . Lubarsky . K. . Badr . N. . Wright . C. . Erisir . A. .
- Kielland. Anders. Erisir. Alev. Walaas. S. Ivar. Heggelund. Paul. 2006-05-24. Synapsin Utilization Differs among Functional Classes of Synapses on Thalamocortical Cells. Journal of Neuroscience. 26. 21. 5786–5793. 10.1523/JNEUROSCI.4631-05.2006 . 16723536 . 6675263 . 6367573 .
- 2011-12-01. Old dogs learning new tricks: Neuroplasticity beyond the juvenile period. Developmental Review. en. 31. 4. 207–239. 10.1016/j.dr.2011.07.008. 0273-2297. 3956134. Lillard . Angeline S. . Erisir . Alev . 24648605 .
- Coleman. Jason E.. Nahmani. Marc. Gavornik. Jeffrey P.. Haslinger. Robert. Heynen. Arnold J.. Erisir. Alev. Bear. Mark F.. 2010-07-21. Rapid Structural Remodeling of Thalamocortical Synapses Parallels Experience-Dependent Functional Plasticity in Mouse Primary Visual Cortex. Journal of Neuroscience. 30. 29. 9670–9682. 10.1523/JNEUROSCI.1248-10.2010 . 20660250 . 3065324 . 54556439 .
- May. Olivia L.. Erisir. Alev. Hill. David L.. 2007. Ultrastructure of primary afferent terminals and synapses in the rat nucleus of the solitary tract: Comparison among the greater superficial petrosal, chorda tympani, and glossopharyngeal nerves. Journal of Comparative Neurology. en. 502. 6. 1066–1078. 10.1002/cne.21371. 17444498 . 1096-9861. 2798003.
Notes and References
- Web site: Episode 01: Alev Erisir, MD PhD. 2021-05-02. Conjugate: Illustration and Science Blog.
- Conkle. Ann. Erwin. Jesse. Wargo. Eric. West. and Catherine. 2008-02-01. Road Trip! APS Visits UVA. APS Observer. 21. 2.
- Book: The History of Neuroscience in Autobiography. 1998. Albright. Thomas. 10. S. Murray Sherman. Squire. Larry.
- Web site: Episode 01: Alev Erisir, MD PhD. 2021-04-27. Conjugate: Illustration and Science Blog. en-US.
- Web site: 2007-02-06. U.Va. Scientists Identify 'Missing Link' in Process Leading to Alzheimer's Disease. 2021-04-28. UVA Today. en.
- News: Ford. Jane. October 14, 2008. TEN PROFESSORS WIN MEAD GRANTS TO FOSTER FACULTY-STUDENT INTERACTION. UVA Today. April 28, 2021.
- Web site: 2010-04-05. U.Va. Awards Eight Double-'Hoo Research Grants. 2021-04-28. UVA Today. en.