| Type: | Bishop |
| Honorific-Prefix: | Most Reverend |
| Alessandro Piccolomini | |
| Bishop of Chiusi | |
| Church: | Catholic Church |
| Diocese: | Diocese of Chiusi |
| Term: | 1657–1661 |
| Predecessor: | Carlo de' Vecchi |
| Successor: | Marco Antonio Marescotti |
| Death Date: | 6 November 1661 |
| Death Place: | Chiusi, Italy |
Alessandro Piccolomini (died 6 November 1661) was a Roman Catholic prelate who served as Bishop of Chiusi (1657–1661).[1]
On 12 March 1657, Alessandro Piccolomini was appointed during the papacy of Pope Alexander VII as Bishop of Chiusi.[2] He served as Bishop of Chiusi until his death on 6 November 1661.