Aldehyde dehydrogenase 9 family, member A1 explained

4-trimethylaminobutyraldehyde dehydrogenase is an enzyme that in humans is encoded by the ALDH9A1 gene.^{[1] [2] [3]}

Function

This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits.^[3]

Further reading

• Kurys G, Ambroziak W, Pietruszko R . Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde . The Journal of Biological Chemistry . 264 . 8 . 4715–21 . March 1989 . 10.1016/S0021-9258(18)83802-9 . 2925663 . free .
• Kurys G, Shah PC, Kikonygo A, Reed D, Ambroziak W, Pietruszko R . Human aldehyde dehydrogenase. cDNA cloning and primary structure of the enzyme that catalyzes dehydrogenation of 4-aminobutyraldehyde . European Journal of Biochemistry . 218 . 2 . 311–20 . December 1993 . 8269919 . 10.1111/j.1432-1033.1993.tb18379.x . free .
• Kikonyogo A, Pietruszko R . Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution . The Biochemical Journal . 316 (Pt 1) . 1 . 317–24 . May 1996 . 8645224 . 1217341 . 10.1042/bj3160317.
• Izaguirre G, Kikonyogo A, Pietruszko R . Tissue distribution of human aldehyde dehydrogenase E3 (ALDH9): comparison of enzyme activity with E3 protein and mRNA distribution . Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology . 118 . 1 . 59–64 . September 1997 . 9417993 . 10.1016/s0305-0491(97)00022-9 .
• Vaz FM, Fouchier SW, Ofman R, Sommer M, Wanders RJ . Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis . The Journal of Biological Chemistry . 275 . 10 . 7390–4 . March 2000 . 10702312 . 10.1074/jbc.275.10.7390 . free .
• Izaguirre G, Pietruszko R, Cho S, MacKerell A . Human aldehyde dehydrogenase catalytic activity and structural interactions with coenzyme analogs . Journal of Biomolecular Structure & Dynamics . 19 . 3 . 429–47 . December 2001 . 11790142 . 10.1080/07391102.2001.10506752 . 35621262 .

Notes and References

1. McPherson JD, Wasmuth JJ, Kurys G, Pietruszko R . Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes gamma-aminobutyraldehyde . Human Genetics . 93 . 2 . 211–2 . February 1994 . 8112751 . 10.1007/bf00210615 . 26773065 .
2. Lin SW, Chen JC, Hsu LC, Hsieh CL, Yoshida A . Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression . Genomics . 34 . 3 . 376–80 . June 1996 . 8786138 . 10.1006/geno.1996.0300 .
3. Web site: Entrez Gene: ALDH9A1 aldehyde dehydrogenase 9 family, member A1.