Alcohol dehydrogenase, iron containing 1 explained

Alcohol dehydrogenase, iron containing 1 is a protein that in humans is encoded by the ADHFE1 gene.^[1]

Function

The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues.^[2]

Further reading

• Deng Y, Wang Z, Gu S, Ji C, Ying K, Xie Y, Mao Y . Cloning and characterization of a novel human alcohol dehydrogenase gene (ADHFe1) . DNA Sequence . 13 . 5 . 301–6 . October 2002 . 12592711 . 10.1080/1042517021000011636 . 24529446 .
• Lyon RC, Johnston SM, Panopoulos A, Alzeer S, McGarvie G, Ellis EM . Enzymes involved in the metabolism of gamma-hydroxybutyrate in SH-SY5Y cells: identification of an iron-dependent alcohol dehydrogenase ADHFe1 . Chemico-Biological Interactions . 178 . 1–3 . 283–7 . March 2009 . 19013439 . 10.1016/j.cbi.2008.10.025 . 2009CBI...178..283L .
• Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ . Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression . PLOS ONE . 5 . 9 . e12862 . September 2010 . 20877624 . 2943476 . 10.1371/journal.pone.0012862 . 2010PLoSO...512862H . free .
• Tae CH, Ryu KJ, Kim SH, Kim HC, Chun HK, Min BH, Chang DK, Rhee PL, Kim JJ, Rhee JC, Kim YH . Alcohol dehydrogenase, iron containing, 1 promoter hypermethylation associated with colorectal cancer differentiation . BMC Cancer . 13 . 142 . March 2013 . 23517143 . 3618294 . 10.1186/1471-2407-13-142 . free .

Notes and References

1. Web site: Entrez Gene: Alcohol dehydrogenase, iron containing 1 . 2017-06-16 .
2. Kardon T, Noël G, Vertommen D, Schaftingen EV . Identification of the gene encoding hydroxyacid-oxoacid transhydrogenase, an enzyme that metabolizes 4-hydroxybutyrate . FEBS Letters . 580 . 9 . 2347–50 . April 2006 . 16616524 . 10.1016/j.febslet.2006.02.082 . 46525441 . free .