| Province: | AB |
| Type: | Hwy |
| Route: | 45 |
| Map: | Alberta Highway 045.png |
| Length Km: | 230.0 |
| Direction A: | West |
| Direction B: | East |
| Terminus A: | south of Bruderheim |
| Junction: |
|
| Terminus B: | at Saskatchewan border |
| Rural Municipalities: | Lamont County, County of Two Hills No. 21, County of Vermilion River |
| Towns: | Bruderheim, Two Hills |
| Villages: | Willingdon, Myrnam, Marwayne |
| Previous Type: | Hwy |
| Previous Route: | 44 |
| Next Type: | Hwy |
| Next Route: | 47 |
Alberta Provincial Highway No. 45, commonly referred to as Highway 45, is an east-west highway in central Alberta, Canada that extends from Highway 15 northeast of Edmonton to the Saskatchewan border. It runs generally parallel to Highway 16 (Yellowhead Highway).[1]
From west to east:[2]