Albert J. R. Heck Explained

Albert J.R. Heck
Birth Date:25 November 1964
Birth Place:Goes, The Netherlands
Nationality:Dutch
Alma Mater:University of Amsterdam
Known For:Proteomics, Native Mass Spectrometry
Workplaces:Utrecht University, University of Warwick, Stanford University, University of Amsterdam
Awards:Descartes-Huygens Prize (2006)
Spinoza Prize (2017)
Sir Hans Krebs Medal (2018)
Doctoral Advisor:Nico M. M. Nibbering
Fields:Physics, Chemistry, Biology

Albert J.R. Heck (born 25 November 1964) is a Dutch scientist and professor at Utrecht University, the Netherlands in the field of mass spectrometry and proteomics. He is known for his work on technologies to study proteins in their natural environment, with the aim to understand their biological function. Albert Heck was awarded the Spinoza Prize in 2017, the highest scientific award in the Netherlands.

Biography

Albert Heck was born in Goes, Netherlands. He studied chemistry at the VU University in Amsterdam, and received his PhD degree from the University of Amsterdam in 1993. After a postdoctoral period at Stanford University in the lab of Richard Zare and Sandia National Laboratories (Livermore) he became a postdoctoral fellow and later lecturer at University of Warwick.

In 1998 he accepted a chair at Utrecht University as head of the Biomolecular Mass Spectrometry and Proteomics Group.[1] His group is part of the Departments of Chemistry and Pharmaceutical Sciences of the Faculty of Science.[2] From 2006 until 2012 Heck was scientific director of the Bijvoet Centre for Biomolecular Research, and from 2015 to 2018 scientific director of the Utrecht Institute for Pharmaceutical Science at Utrecht University. In 2017 he received a Distinguished Faculty professorship of Utrecht University.[3]

Research

The research of Albert Heck is focused on the development and use of mass spectrometry to study all cellular proteins. Within his research group, there are three main lines of research, improvement of instrumentation and analytical methods, proteomics and mass spectrometry based structural biology, including native protein mass spectrometry and cross-linking mass spectrometry.

Albert Heck is regarded as one of the pioneers of native mass spectrometry.[4] [5] [6] Among the complexes that he studied using native mass spectrometry are intact viruses of up to 18 megadalton,[7] [8] ribosomes,[9] antibodies in complex with their antigens[10] or proteins of the complement system.[11] [12] He has developed, in collaboration with Alexander Makarov mass spectrometers with extended mass ranges, specifically suited for the analyses of very large protein complexes, which were later commercialized by the company ThermoFisher Scientific as the Orbitrap EMR and UHMR.

In proteomics, Heck is most renowned for his work on quantitative proteomics,[13] [14] interactomics,[15] and the analysis of post-translational modification of proteins using mass spectrometry, with a focus on protein phosphorylation[16] and protein glycosylation.[17] This started with the introduction of the material TiO2 as a method for the targeted analysis of phosphopeptides in 2004.[18] The methods developed by Heck have been adopted by many scientists in other fields, to study how protein expression and phosphorylation are regulated in human cells and tissues by different biological processes and disease states.[19] [20]

Additionally, he advocated the use of complementary proteases in shot-gun proteomics[21] [22] and he introduced and developed novel peptide fragmentation strategies to elucidate site specific post-translational modifications.[23] The latter improves determination of peptide and protein sequence information, which is particular helpful for the analysis of glycopeptides[24] and HLA antigens.[25] [26] Heck also contributed to the field of cross-linking mass spectrometry, through proteome wide cross-linking experiments,[27] and the development of novel fragmentation methods and the software suite XlinkX.[28]

Albert Heck is closely involved in coordinating access to proteomics infrastructures in the Netherlands and in Europe. Since 2003 Heck is scientific director of the Netherlands Proteomics Centre.[29] From 2011 to 2015 he was coordinator of PRIME-XS,[30] and since 2019 he coordinates EPIC-XS,[31] both collaborative projects funded by the European Union to enable access to proteomics technology for researchers throughout Europe.

Honours and awards

Heck received numerous awards and prizes for his scientific contributions. He received The KNCV golden medal in 2001,[32] the Descartes-Huygens Prize from the Académie de Sciences in 2006,[33] the Life Science Award of the German Mass Spectrometry Society in 2010, the Discovery Award in Proteomic Sciences from the Human Proteome Organization in 2013[34] and the UePA Pioneer Proteomics Award in 2014.

Since 2014 he is a member of the European Molecular Biology Organization.[35] [36] In 2014, Heck was elected a member of the Royal Netherlands Academy of Arts and Sciences.[37] The American Chemical Society honoured Albert Heck with the 'Frank H. Field and Joe L. Franklin Award for Outstanding Achievements in Mass Spectrometry' in 2015.[38]

In 2017, he was awarded the Spinoza Prize, the highest scientific distinction in the Netherlands for his "major contribution to the worldwide breakthrough of systematically mapping all proteins in human cells and their biological functions by means of mass spectrometry".[39]

In 2018, he received the Sir Hans Krebs Medal of the Federation of European Biochemical Societies (FEBS) and the Thomson Medal Award of the International Mass Spectrometry Society (IMSC).[40]

External links

Notes and References

  1. Web site: Catalogus Professorum: Prof.dr. A.J.R. Heck. UU. 29 November 2019.
  2. News: Hoogleraren. 21 May 2014. Volkskrant. 5 September 2012. Dutch .
  3. Web site: Albert Heck appointed Distinguished Professor of the Faculty of Science. 1 November 2017. 7 January 2020.
  4. Web site: Awards – 2013 Recipients. 21 May 2014. HUPO .
  5. Leney. Aneika C.. Heck. Albert J. R.. 2017. Native Mass Spectrometry: What is in the Name?. Journal of the American Society for Mass Spectrometry. 28. 1. 5–13. 2017JASMS..28....5L. 10.1007/s13361-016-1545-3. 5174146. 27909974.
  6. News: Grote complexen intact de MS in. 7 June 2013. Chemisch2Weekblad (C2W). Dutch.
  7. 10.1021/ja502616y. 24787140. 4046769. Defining the Stoichiometry and Cargo Load of Viral and Bacterial Nanoparticles by Orbitrap Mass Spectrometry. Journal of the American Chemical Society. 136. 20. 7295–7299. 2014. Snijder. Joost. Van De Waterbeemd. Michiel. Damoc. Eugen. Denisov. Eduard. Grinfeld. Dmitry. Bennett. Antonette. Agbandje-Mckenna. Mavis. Makarov. Alexander. Heck. Albert J. R..
  8. 10.1002/anie.201008120. 21793131. Modern Biomolecular Mass Spectrometry and its Role in Studying Virus Structure, Dynamics, and Assembly. Angewandte Chemie International Edition. 50. 36. 8248–8262. 2011. Uetrecht. Charlotte. Heck. Albert J. R.. 7159578.
  9. 10.1038/s41467-018-04853-x. 29950687. 6021402. Dissecting ribosomal particles throughout the kingdoms of life using advanced hybrid mass spectrometry methods. Nature Communications. 9. 1. 2493. 2018. Van De Waterbeemd. Michiel. Tamara. Sem. Fort. Kyle L.. Damoc. Eugen. Franc. Vojtech. Bieri. Philipp. Itten. Martin. Makarov. Alexander. Ban. Nenad. Heck. Albert J. R.. 2018NatCo...9.2493V.
  10. 10.1002/anie.201206745. 23172610. Exploring an Orbitrap Analyzer for the Characterization of Intact Antibodies by Native Mass Spectrometry. Angewandte Chemie International Edition. 51. 52. 12992–12996. 2012. Rosati. Sara. Rose. Rebecca J.. Thompson. Natalie J.. Van Duijn. Esther. Damoc. Eugen. Denisov. Eduard. Makarov. Alexander. Heck. Albert J. R.. free.
  11. 10.1016/j.molcel.2016.05.016. 27320199. Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen. Molecular Cell. 63. 1. 135–145. 2016. Wang. Guanbo. De Jong. Rob N.. Van Den Bremer. Ewald T.J.. Beurskens. Frank J.. Labrijn. Aran F.. Ugurlar. Deniz. Gros. Piet. Schuurman. Janine. Parren. Paul W.H.I.. Heck. Albert J.R.. free.
  12. News: Een moleculaire rattenkoning slaat groot immuunalarm. 15 March 2014. NRC Handelsblad. Dutch.
  13. 10.1038/nbt848. 12858183. Metabolic labeling of C. Elegans and D. Melanogaster for quantitative proteomics. Nature Biotechnology. 21. 8. 927–931. 2003. Krijgsveld. Jeroen. Ketting. René F.. Mahmoudi. Tokameh. Johansen. Janik. Artal-Sanz. Marta. Verrijzer. C. Peter. Plasterk. Ronald H. A.. Heck. Albert J. R.. 2641430.
  14. 10.1038/nprot.2009.21. 19300442. Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics. Nature Protocols. 4. 4. 484–494. 2009. Boersema. Paul J.. Raijmakers. Reinout. Lemeer. Simone. Mohammed. Shabaz. Heck. Albert J. R.. 5498505.
  15. 10.1074/mcp.RA117.000470. 29222160. 5795388. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Molecular & Cellular Proteomics. 17. 2. 216–232. 2018. Liu. Fan. Lössl. Philip. Rabbitts. Beverley M.. Balaban. Robert S.. Heck. Albert J. R.. free .
  16. News: Moeilijk te vangen fosforgroepen. Chemisch2Weekblad (C2W) Life Sciences. 23 June 2012. Dutch.
  17. 10.1016/j.tibtech.2017.04.010. 28527536. Glycoproteomics: A Balance between High-Throughput and In-Depth Analysis. Trends in Biotechnology. 35. 7. 598–609. 2017. Yang. Yang. Franc. Vojtech. Heck. Albert J.R.. 1874/351003. free.
  18. 10.1021/ac0498617. 15253627. Selective Isolation at the Femtomole Level of Phosphopeptides from Proteolytic Digests Using 2D-NanoLC-ESI-MS/MS and Titanium Oxide Precolumns. Analytical Chemistry. 76. 14. 3935–3943. 2004. Pinkse. Martijn W. H.. Uitto. Pauliina M.. Hilhorst. Martijn J.. Ooms. Bert. Heck. Albert J. R..
  19. 10.1016/j.cels.2019.08.005. 31521607. 6838672. High-Throughput Assessment of Kinome-wide Activation States. Cell Systems. 9. 4. 366–374.e5. 2019. Schmidlin. Thierry. Debets. Donna O.. Van Gelder. Charlotte A.G.H.. Stecker. Kelly E.. Rontogianni. Stamatia. Van Den Eshof. Bart L.. Kemper. Kristel. Lips. Esther H.. Van Den Biggelaar. Maartje. Peeper. Daniel S.. Heck. Albert J.R.. Altelaar. Maarten.
  20. 10.1016/j.stem.2009.05.021. 19664995. Phosphorylation Dynamics during Early Differentiation of Human Embryonic Stem Cells. Cell Stem Cell. 5. 2. 214–226. 2009. Van Hoof. Dennis. Muñoz. Javier. Braam. Stefan R.. Pinkse. Martijn W.H.. Linding. Rune. Heck. Albert J.R.. Mummery. Christine L.. Krijgsveld. Jeroen. free.
  21. 10.1038/nprot.2016.057. 27123950. Six alternative proteases for mass spectrometry–based proteomics beyond trypsin. Nature Protocols. 11. 5. 993–1006. 2016. Giansanti. Piero. Tsiatsiani. Liana. Low. Teck Yew. Heck. Albert J. R.. 1874/333986. 2597839. free.
  22. 10.1111/febs.13287. 25823410. Proteomics beyond trypsin. FEBS Journal. 282. 14. 2612–2626. 2015. Tsiatsiani. Liana. Heck. Albert J. R.. 24903856. free.
  23. 10.1021/ac3025366. 23106539. Toward Full Peptide Sequence Coverage by Dual Fragmentation Combining Electron-Transfer and Higher-Energy Collision Dissociation Tandem Mass Spectrometry. Analytical Chemistry. 84. 22. 9668–9673. 2012. Frese. Christian K.. Altelaar. A. F. Maarten. Van Den Toorn. Henk. Nolting. Dirk. Griep-Raming. Jens. Heck. Albert J. R.. Mohammed. Shabaz.
  24. 10.1016/j.trac.2018.09.007. The benefits of hybrid fragmentation methods for glycoproteomics. Trends in Analytical Chemistry. 108. 260–268. 2018. Reiding. Karli R.. Bondt. Albert. Franc. Vojtech. Heck. Albert J.R.. 1874/373361. 105377340. free.
  25. 10.1073/pnas.1321458111. 24616531. Expanding the detectable HLA peptide repertoire using electron-transfer/Higher-energy collision dissociation (EThcD). Proceedings of the National Academy of Sciences. 111. 12. 4507–4512. 2014. Mommen. G. P. M.. Frese. C. K.. Meiring. H. D.. Van Gaans-Van Den Brink. J.. De Jong. A. P. J. M.. Van Els. C. A. C. M.. Heck. A. J. R.. 3970485. 2014PNAS..111.4507M. free.
  26. 10.1126/science.aaf4384. 27846572. A large fraction of HLA class I ligands are proteasome-generated spliced peptides. Science. 354. 6310. 354–358. 2016. Liepe. Juliane. Marino. Fabio. Sidney. John. Jeko. Anita. Bunting. Daniel E.. Sette. Alessandro. Kloetzel. Peter M.. Stumpf. Michael P. H.. Heck. Albert J. R.. Mishto. Michele. 2016Sci...354..354L. 10044/1/42330. 41095551. free.
  27. 10.1038/nmeth.3603. 26414014. Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry. Nature Methods. 12. 12. 1179–1184. 2015. Liu. Fan. Rijkers. Dirk T. S.. Post. Harm. Heck. Albert J. R.. 1874/329447. 6786537. free.
  28. 10.1038/ncomms15473. 28524877. Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification. Nature Communications. 8. 15473. 2017. Liu. Fan. Lössl. Philip. Scheltema. Richard. Viner. Rosa. Heck. Albert J. R.. 5454533. 2017NatCo...815473L. free.
  29. Web site: Proteins At Work. The Analytical Scientist. 23 February 2014.
  30. PRIME-XS, a European infrastructure for proteomics.. Molecular & Cellular Proteomics. 13. 8. 1901–1904. 10.1074/mcp.E114.040162. 24958170. 4125724. 2014. Raijmakers. Reinout. Olsen. Jesper V.. Aebersold. Ruedi. Heck. Albert J. R.. free.
  31. Web site: Proteomics Experts Unite for EPIC-XS. Technology Networks. 22 March 2019. 29 November 2019.
  32. Web site: Overzicht KNCV Gouden Medaille Winnaars. NL. KNCV. 29 November 2019.
  33. Web site: Descartes-Huygens Prize. KNAW. 29 November 2019. 22 March 2019. https://web.archive.org/web/20190322164033/https://www.knaw.nl/en/awards/laureates/descartes-huygens-prize. dead.
  34. Web site: 2 October 2013. Most important international proteomics award for Albert Heck. 21 May 2014. Netherlands Genomics Initiative.
  35. Web site: EMBO announces new members for 2013. 21 May 2014. EMBO. 21 May 2014 .
  36. Web site: Albert Heck en Ineke Braakman verkozen tot EMBO leden. 21 May 2014. Utrecht University. 19 May 2014. Dutch .
  37. Web site: KNAW kiest zeventien nieuwe leden. 21 May 2014. KNAW. 21 May 2014. Dutch .
  38. Web site: 28 August 2015. Prestigious American Chemical Society awards for Albert Heck and Geert-Jan Boons. 28 November 2019. UU.
  39. Web site: NWO Spinoza Prizes awarded to Eveline Crone, Albert Heck, Michel Orrit and Alexander van Oudenaarde. NWO. 6 June 2017. 28 November 2019.
  40. Web site: Professor Albert Heck is to receive two international distinctions. UU. 3 July 2018. 28 November 2019.

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