| State: | AL |
| Type: | AL |
| Route: | 64 |
| Map Custom: | yes |
| Length Mi: | 18.230 |
| Length Ref: | [1] |
| Established: | 1940 |
| Direction A: | West |
| Direction B: | East |
| Terminus A: | south of the Tennessee state line |
| Junction: | in Lexington |
| Terminus B: | north of Anderson |
| Counties: | Lauderdale |
| Previous Type: | SR |
| Previous Route: | 63 |
| Next Type: | I |
| Next Route: | 65 |
State Route 64 (SR 64) is an 18.23adj=midNaNadj=mid east–west state highway entirely within Lauderdale County in the northwest portion of the U.S. state of Alabama. The western terminus of the highway is at an intersection with U.S. Route 43 (US 43) near Green Hill, an unincorporated community south of the Tennessee state line. The eastern terminus of the highway is at an intersection with SR 207 north of Anderson.
SR 64 travels along a two-lane roadway as it travels through northern Lauderdale County. The highway connects the small towns of Anderson and Lexington with US 43, which heads southward into Florence and Muscle Shoals.