| State: | AL |
| Type: | SR |
| Route: | 143 |
| Map Custom: | yes |
| Length Mi: | 28.598 |
| Length Ref: | [1] |
| Established: | 1957[2] [3] |
| Direction A: | South |
| Terminus A: | northwest of Montgomery |
| Direction B: | North |
| Terminus B: | near Clanton |
| Previous Type: | SR |
| Previous Route: | 142 |
| Next Type: | SR |
| Next Route: | 144 |
State Route 143 (SR 143) is a 28.598adj=midNaNadj=mid north–south state highway in the central part of the U.S. state of Alabama, extending north from Interstate 65 (I-65) and U.S. Route 82 (US 82) northwest of Montgomery to US 31 near Clanton. It parallels I-65, traveling through Millbrook, Elmore, and Deatsville.
Prior to the 1957 renumbering, SR 143 was numbered State Route 45; it was renumbered because of US 45.[2] [3]
Prior to the construction of I-65, SR 143 crossed the Alabama River on the Tyler–Goodwyn Bridge and entered Montgomery on Parallel Street. The bridge, scene of the murder of Willie Edwards, was subsequently removed.[4]