Akiko Iwasaki Explained

Akiko Iwasaki
岩崎明子
Birth Date:13 September 1970
Birth Place:Iga, Mie Prefecture, Japan
Nationality:American
Education:University of Toronto, National Institutes of Health
Fields:Immunobiology, Molecular Biology, Cellular Biology, Developmental Biology
Workplaces:Yale University, Howard Hughes Medical Institute
Awards:National Academy of Medicine Elected Member
Children:2

is a Sterling Professor of Immunobiology and Molecular, Cellular and Developmental Biology at Yale University.[1] She is also a principal investigator at the Howard Hughes Medical Institute. Her research interests include innate immunity, autophagy, inflammasomes, sexually transmitted infections, herpes simplex virus, human papillomavirus, respiratory virus infections, influenza infection, T cell immunity, commensal bacteria, COVID-19, and long COVID.

Iwasaki was elected to the National Academy of Sciences in 2018.[2] She is the 2023–2024 president of the American Association of Immunologists.[3]

Biography

Iwasaki was born and raised in Iga, Japan by her father Hiroshi, a physicist, and mother Fumiko, who fought for women's rights in the workplace.[4] She has two sisters. After high school she moved to Toronto, Canada, where in 1994, she received her bachelor's degree in biochemistry and physics from the University of Toronto. She had hopes of becoming a mathematician or physicist like her father. However, her interests changed after taking an immunology class.[5]

Iwasaki earned her doctoral degree in immunology from the University of Toronto in 1998. Iwasaki did her postdoctoral fellow at the National Institutes of Health in the lab of mucosal immunologist Brian Lee Kelsall. In 2000, she started her own lab at Yale University. In 2022, Iwasaki was awarded a Sterling Professorship, the highest academic honor professors receive at Yale University.[6]

Major contributions

While working on her PhD project of how DNA vaccines elicit an immune response, Iwasaki was among the first to show that antigen-presenting cells were in the blood, not the muscle. At the time scientists thought muscle cells were essential for alerting the immune system of foreign proteins, or antigens, coded for by the vaccines because the DNA vaccines work best when injected into the muscle.[5]

Iwasaki's research continues to focus on understanding innate immunity and how that information is used to produce protective adaptive immunity. Iwasaki and her team study immune responses to influenza in the lungs and herpes simplex virus in the genital tract. Overall, the goal is to design effective vaccines or microbiocides for the prevention of transmission of viral and bacterial pathogens.[7] Iwasaki has developed a two-stage vaccination strategy called "prime and pull" that involves a conventional vaccine as a first step and then application of chemokines to the target tissue as a second step. Based on this strategy, Iwasaki has developed a vaccine that is currently in a clinical trial to treat women with precancerous lesions in the cervix to prevent cervical cancer. Serving on Yale University's Science Strategy Committee, Iwasaki has advocated for harnessing the beneficial aspects of inflammation to "combat widespread diseases like stroke, heart disease, and diabetes".[8]

Building on her interests in immune responses to viral infection, Iwasaki has also led research into human rhinovirus and Zika virus. Iwasaki's group was notably the first to create a mouse model of a vaginal Zika infection. Most recently, Iwasaki has delved into research looking at the immune response of COVID-19 patients and sex differences in SARS-CoV-2 infection.[9] [10] [11] She is also examining the effects of Long COVID and other syndromes that occur following acute infections.[12]

According to Google Scholar, one of her publications, "Toll-like receptor control of the adaptive immune response,"[13] has been cited over 5,300 times as of August 2023 and was published in Nature Immunology in October 2004.[14] In January 2015, one of Iwasaki's studies was published in the Proceedings of the National Academy of Sciences. The study, "Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells", investigates the relationship between temperature and immune responses.[15]

Personal life

Iwasaki is well known as an advocate for women in science, including voicing support for affordable childcare.[16] [17] Additionally, she has spoken out in support of immigrants and their contributions to science.[18] Iwasaki has gained a following on Twitter for her public health advice about COVID-19, advocating for social distancing early in the pandemic.[19] [20] [21]

She is married to Ruslan Medzhitov, a professor of immunobiology at Yale School of Medicine. They have two daughters.[22] [23]

Honors

Publications

Notes and References

  1. Web site: Brian . Zhang . 2022-03-02 . Akiko Iwasaki named Sterling Professor . 2022-03-07 . Yale Daily News . en.
  2. Web site: Six Yale professors elected to National Academy of Sciences . yale.edu . December 28, 2020 . May 1, 2018.
  3. Web site: 2023 AAI Election . May 24, 2023 . The American Association of Immunologists.
  4. Viegas. Jennifer. 2018-12-11. Profile of Akiko Iwasaki. Proceedings of the National Academy of Sciences of the United States of America. 115. 50. 12544–12546. 10.1073/pnas.1818903115. 0027-8424. 6294888. 30509976. 2018PNAS..11512544V . free.
  5. Web site: Akiko Iwasaki, PhD. Howard Hughes Medical Institute Our Scientists. Howard Hughes Medical Institute. 4 May 2015.
  6. Web site: Iwasaki Is Named a Sterling Professor. 2022-02-25. medicine.yale.edu. en.
  7. Web site: Akiko Iwasaki PhD . 4 May 2015 . Yale University Biological & Biomedical Sciences . Yale University.
  8. Web site: Belli. Brita. 2018-11-14. At alumni assembly, leading faculty address Yale's future in the sciences. 2020-07-12. YaleNews. en.
  9. Web site: 2020-07-06. COVID-19 Research: Women Are Changing the Face of the Pandemic. 2020-07-12. GEN - Genetic Engineering and Biotechnology News. en-US.
  10. Web site: Forman. Robert. Gift from Ludwig Family Foundation Funds Urgent COVID Research by School of Medicine Scientists. 2020-07-12. Yale School of Medicine. en.
  11. Web site: Why Men May Fare Worse than Women Against SARS-CoV-2. 2020-07-12. HHMI.org. en.
  12. News: Akiko Iwasaki, PhD, on the latest long COVID-19 research . 10 August 2022 . American Medical Association . April 11, 2022 . en.
  13. Web site: Iwasaki. Akiko. Toll-like receptor control of the adaptive immune response. Nature Immunology. Nature Publishing Group. 4 May 2015. https://web.archive.org/web/20150518093007/http://iwasakilab.sites.yale.edu/sites/default/files/ni1112.pdf. 18 May 2015. dead.
  14. Web site: Google Scholar. 2020-07-12. scholar.google.com.
  15. Web site: Cold virus replicates better at cooler temperatures. 2020-07-12. ScienceDaily. en.
  16. Web site: Matt. Kristoffersen. February 25, 2020. Postdocs struggle with child care costs. 2020-07-12. yaledailynews.com. en.
  17. Web site: Kristoffersen. Matt. Helena. Lyng-Olsen. October 14, 2019. Professors question gender inequity of Nobel laureates. 2020-07-12. yaledailynews.com. en.
  18. Web site: 2020-06-25. Scientists and Societies Decry Trump Executive Order on Immigration Visas. 2020-07-12. GEN - Genetic Engineering and Biotechnology News. en-US.
  19. Web site: Belli. Brita. 2020-03-16. Amid coronavirus crisis, Yale scientists find useful tool in Twitter. 2020-07-12. YaleNews. en.
  20. Web site: Kaufman. Mark. Who to follow on Twitter for legit, trustworthy coronavirus info. 2020-07-12. Mashable. 24 April 2020 . en.
  21. Web site: Kaufman. Mark. We have a potent weapon against coronavirus. We should use it.. 2020-07-12. Mashable. 12 March 2020 . en.
  22. Web site: Heeding the call of basic research. 2020-09-12. Yale School of Medicine. en.
  23. Web site: Profile: Akiko Iwasaki. 2020-09-12. British Society of Immunology. en. 2021-06-24. https://web.archive.org/web/20210624205454/https://www.immunology.org/profile-akiko-iwasaki. dead.
  24. Web site: 2019 Seymour & Vivian Milstein Award for Excellence in Interferon and Cytokine Research. 2019-04-22. International Cytokine & Interferon Society. en-US. 2019-04-23.
  25. Web site: New Members. 2021-04-24. American Academy of Arts & Sciences. en.
  26. Web site: Meislin . Margy . 2022-06-22 . Lupus Research Alliance Awards 2022 Lupus Insight Prize to Immunologist Dr. Akiko Iwasaki: Renowned immunology expert honored . 2024-02-22 . Lupus Research . en-US.
  27. Web site: Else Kröner Fresenius Prize for Medical Research 2023 . 2023-05-08 . Else Kröner-Fresenius-Stiftung.
  28. Web site: Meislin . Margy . 2024-01-30 . Lupus Research Alliance 2023 Dr. William E. Paul Distinguished Innovator Award Granted to Yale School of Medicine Researcher Akiko Iwasaki, Ph.D. . 2024-02-22 . Lupus Research . en-US.

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