Aigialomycin D Explained

Aigialomycin D is a macrolide antibiotic which is produced by the fungi Aigialus parvus.^[1] Aigialomycin D is a resorcylic acid lactone and has the molecular formula C₁₈H₂₂O₆.^[2] Preliminary studies found that aigialomycin D is a protein kinase inhibitor^[3] with anti-tumor activity. Aigialomycin D has antimalarial activity.^[4]

Further reading

• Geng . Xudong . Danishefsky . Samuel J. . Total Synthesis of Aigialomycin D . Organic Letters . 1 February 2004 . 6 . 3 . 413–416 . 10.1021/ol036258m. 14748606 .
• Book: Studies in Natural Products Chemistry . 20 January 2015 . Elsevier . 978-0-444-63470-2 . 386 . en.
• Book: Taber . Douglass . Organic Synthesis: State of the Art 2007 - 2009 . 23 September 2011 . Oxford University Press . 978-0-19-020877-6 . 101 . en.

Notes and References

1. Book: Blunt . John W. . Munro . Murray H. G. . Dictionary of Marine Natural Products with CD-ROM . 19 September 2007 . CRC Press . 978-0-8493-8217-8 . 32 . en.
2. Xu . Jin . Chen . Anqi . Go . Mei-Lin . Nacro . Kassoum . Liu . Boping . Chai . Christina L. L. . Exploring Aigialomycin D and Its Analogues as Protein Kinase Inhibitors for Cancer Targets . ACS Medicinal Chemistry Letters . 8 September 2011 . 2 . 9 . 662–666 . 10.1021/ml200067t. 24900361 . 4018073 .
3. Book: Advances in Phosphotransferases (Alcohol Group Acceptor) Research and Application: 2012 Edition . 26 December 2012 . ScholarlyEditions . 978-1-4649-9201-8 . 76 . en.
4. Book: Tiwari . Vinod K. . Carbohydrates in Drug Discovery and Development: Synthesis and Application . 31 July 2020 . Elsevier . 978-0-12-816676-5 . 508 . en.