| Ahafo Ano South District | |
| Settlement Type: | Former District |
| Pushpin Map: | Ghana |
| Pushpin Map Caption: | Location of Ahafo Ano South District within Ashanti |
| Subdivision Type: | Country |
| Subdivision Name: |  Ghana |
| Subdivision Type1: | Region |
| Subdivision Type2: | Capital |
| Subdivision Name2: | Mankranso |
| Leader Title: | District Executive |
| Leader Name: | Kwaku Obeng Boateng |
| Area Total Km2: | 1126 |
| Population As Of: | 2010 |
| Population Total: | 121,659 |
| Timezone: | GMT |
| Utc Offset: | +0 |
| Coordinates: | 6.8167°N -53°W |
Ahafo Ano South District is a former district that was located in Ashanti Region, Ghana. Originally created as an ordinary district assembly in 1988, which was created from the former Ahafo Ano District Council. However, on 15 March 2018, it was split off into two new districts: Ahafo Ano South West District (capital: Mankranso) and Ahafo Ano South East District (capital: Adugyama). The district assembly was located in the western part of Ashanti Region and had Mankranso as its capital town.
As of the 2010 Ghana Population Census, Ahafo Ano South had a population of 121,659.[1]