| Aguirre Department | |
| Native Name Lang: | es |
| Settlement Type: | Department |
| Mapsize: | 180px |
| Pushpin Map Caption: | Location of Aguirre Department in Argentina |
| Coordinates: | -29.1333°N -101°W |
| Coor Pinpoint: | Pinto |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Name1: | Santiago del Estero |
| Seat Type: | Head town |
| Seat: | Pinto |
| Unit Pref: | Metric |
| Area Total Km2: | 3692 |
| Population Total: | 7610 |
| Population As Of: | 2010 |
| Population Density Km2: | auto |
| Timezone1: | ART |
| Utc Offset1: | -3 |
Aguirre Department is a department of Santiago del Estero Province, Argentina. The capital lies at Pinto.
The department covers an area of 3692 km². The population as of 2010 was 7,610. Municipalities include Argentina, Casares and Malbrán.